Blitzer P H
Cancer. 1985 Apr 1;55(7):1468-72. doi: 10.1002/1097-0142(19850401)55:7<1468::aid-cncr2820550708>3.0.co;2-m.
This is a reanalysis of the data from the Radiation Therapy Oncology Group (RTOG) study of the palliation of metastasis to bone. The RTOG multicenter clinical trial studied pain relief in 759 patients randomly assigned to a variety of dose-fractionation schedules: 270 cGy X 15 fractions, 300 X 10, 300 X 5,400 X 5, and 500 X 5. The multivariate statistical technique of logistic regression was used. The results differed from a previous report in that number of fractions was statistically significantly related to complete combined relief (that is, absence of pain and cessation of the use of narcotics). Also, the time dose factor (TDF) isoeffect conversion did not accurately predict tumor response. The conclusion is that protracted dose-fractionation schedules are more effective than short course schedules.
这是对放射治疗肿瘤学组（RTOG）关于骨转移姑息治疗研究数据的重新分析。RTOG的多中心临床试验研究了759例随机分配到各种剂量分割方案的患者的疼痛缓解情况：270厘戈瑞（cGy）×15次分割、300×10次、300×5次、400×5次和500×5次。使用了逻辑回归的多变量统计技术。结果与之前的报告不同，即分割次数与完全联合缓解（即无疼痛和停止使用麻醉剂）在统计学上有显著关联。此外，时间剂量因子（TDF）等效效应转换不能准确预测肿瘤反应。结论是，延长剂量分割方案比短疗程方案更有效。
