Lipsker Dan, Bessis Didier, Cosnes Anne, Kluger Nicolas, Lutz Virginie, Sauleau Erik, Francès Camille
Université de Strasbourg, Faculté de Médecine, Clinique Dermatologique, Strasbourg, France.
Université Montpellier I, Service de Dermatologie, CHU de Montpellier, Montpellier, France.
Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 91):S23-5. Epub 2015 Mar 10.
Some authors consider that morphoea and systemic sclerosis (SSc) could be part of the same disease spectrum. The aim of this study was to analyse the prevalence of signs indicative of SSc in a cohort of patients with morphoea.
This is a prospective multi-centre study performed in four French academic dermatology departments: 76 patients with morphoea and 101 age- and sex-matched controls, who underwent complete clinical examination, were enrolled. A systemic search for signs indicative of SSc (e.g. Raynaud's phenomenon, reflux) was performed with the help of a standardised questionnaire.
There were 58 women and 18 men (ration=3/1) with a median age of 59 years. Mean age at diagnosis was 54 years (extremes, 13-87). 49 subjects had plaque morphoea, 9 had generalised morphoea and 18 had linear morphoea. Mean duration of morphoea was 7.9 years. Signs possibly indicative of SSc were noted in four patients of the control group and in 8 patients with morphoea. This difference was not statistically significant (p=0.129). Further investigations ruled out SSc in all patients.
Signs indicative of SSc are statistically not more frequently present in patients with morphoea than in controls and this study does not support the view that those 2 entities are part of a common disease spectrum.
一些作者认为硬斑病和系统性硬化症（SSc）可能属于同一疾病谱。本研究的目的是分析硬斑病患者队列中提示SSc的体征的患病率。
这是一项在四个法国学术皮肤科部门进行的前瞻性多中心研究：招募了76例硬斑病患者和101例年龄及性别匹配的对照者，他们均接受了全面的临床检查。借助标准化问卷对提示SSc的体征（如雷诺现象、反流）进行了系统筛查。
共有58名女性和18名男性（比例为3/1），中位年龄为59岁。诊断时的平均年龄为54岁（范围为13 - 87岁）。49名受试者患有斑块状硬斑病，9名患有泛发性硬斑病，18名患有线状硬斑病。硬斑病的平均病程为7.9年。对照组中有4名患者和硬斑病患者中有8名患者出现了可能提示SSc的体征。这种差异无统计学意义（p = 0.129）。进一步检查排除了所有患者的SSc。
提示SSc的体征在硬斑病患者中的出现频率在统计学上并不高于对照组，本研究不支持这两种疾病属于同一疾病谱的观点。
