Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, Uttar Pradesh, India.
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
J Infect Public Health. 2015 Jul-Aug;8(4):341-5. doi: 10.1016/j.jiph.2015.02.002. Epub 2015 Mar 19.
Increased vancomycin minimum inhibitory concentration (MIC) levels in Staphylococcus aureus and their association with vancomycin treatment failure are well-known problems. Few studies have recognized progressive increases in glycopeptide MIC levels for S. aureus strains in recent years. This study determined glycopeptide and daptomycin susceptibility among methicillin resistant S. aureus (MRSA) strains. A total of 776 clinical isolates of MRSA recovered from 2009 to 2012 were studied for glycopeptide and daptomycin susceptibility using the E-test method. The vancomycin MIC geometric mean (GM) of the MRSA isolates was 0.923, 0.944, 1.134 and 1.294 mg/L in the years 2009, 2010, 2011 and 2012, respectively, and the trend significantly increased over the years (P < 0.0001). Similarly, the teicoplanin MIC GM was 1.47, 1.49, 1.8 and 2.04 mg/L in the years from 2009 to 2012, respectively (P < 0.0001). MIC shifts were not found for daptomycin (P > 0.232). A significant increase in the MIC for glycopeptides was observed among the clinical MRSA isolates at our center over a 4-year period. However, the daptomycin MIC did not increase in the observed MRSA isolates.
金黄色葡萄球菌万古霉素最小抑菌浓度（MIC）水平升高及其与万古霉素治疗失败的相关性是众所周知的问题。近年来，很少有研究认识到金黄色葡萄球菌菌株糖肽 MIC 水平的逐渐升高。本研究确定了耐甲氧西林金黄色葡萄球菌（MRSA）菌株中糖肽和达托霉素的敏感性。使用 E 试验法对 2009 年至 2012 年期间从 776 例临床分离的耐甲氧西林金黄色葡萄球菌分离株进行了糖肽和达托霉素敏感性研究。MRSA 分离株的万古霉素 MIC 几何平均值（GM）在 2009 年、2010 年、2011 年和 2012 年分别为 0.923、0.944、1.134 和 1.294 mg/L，多年来呈显著上升趋势（P<0.0001）。同样，替考拉宁 MIC GM 分别为 1.47、1.49、1.8 和 2.04 mg/L，2009 年至 2012 年呈逐年上升趋势（P<0.0001）。达托霉素 MIC 未发生转移（P>0.232）。在我们中心，在 4 年的时间里，临床分离的耐甲氧西林金黄色葡萄球菌对糖肽的 MIC 显著增加。然而，在观察到的耐甲氧西林金黄色葡萄球菌分离株中，达托霉素 MIC 没有增加。
