剂量校准仪线性测试：（99m）锝与（18）氟放射性同位素

Dose calibrator linearity test: (99m)Tc versus (18)F radioisotopes.

作者信息

Willegaignon José, Sapienza Marcelo Tatit, Coura-Filho George Barberio, Garcez Alexandre Teles, Alves Carlos Eduardo Gonzalez Ribeiro, Cardona Marissa Anabel Rivera, Gutterres Ricardo Fraga, Buchpiguel Carlos Alberto

机构信息

PhD, Head Physicist at the Service of Nuclear Medicine of Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (Icesp), São Paulo, SP, Brazil.

Private Docent, Professor, Department of Radiology and Oncology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.

出版信息

Radiol Bras. 2015 Jan-Feb;48(1):26-32. doi: 10.1590/0100-3984.2014.0018.

DOI:10.1590/0100-3984.2014.0018

PMID:25798005

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4366026/

Abstract

OBJECTIVE

The present study was aimed at evaluating the viability of replacing (18)F with (99m)Tc in dose calibrator linearity testing.

MATERIALS AND METHODS

The test was performed with sources of (99m)Tc (62 GBq) and (18)F (12 GBq) whose activities were measured up to values lower than 1 MBq. Ratios and deviations between experimental and theoretical (99m)Tc and (18)F sources activities were calculated and subsequently compared.

RESULTS

Mean deviations between experimental and theoretical (99m)Tc and (18)F sources activities were 0.56 (± 1.79)% and 0.92 (± 1.19)%, respectively. The mean ratio between activities indicated by the device for the (99m)Tc source as measured with the equipment pre-calibrated to measure (99m)Tc and (18)F was 3.42 (± 0.06), and for the (18)F source this ratio was 3.39 (± 0.05), values considered constant over the measurement time.

CONCLUSION

The results of the linearity test using (99m)Tc were compatible with those obtained with the (18)F source, indicating the viability of utilizing both radioisotopes in dose calibrator linearity testing. Such information in association with the high potential of radiation exposure and costs involved in (18)F acquisition suggest (99m)Tc as the element of choice to perform dose calibrator linearity tests in centers that use (18)F, without any detriment to the procedure as well as to the quality of the nuclear medicine service.

摘要

目的

本研究旨在评估在剂量校准器线性测试中用（99m）锝替代（18）氟的可行性。

材料与方法

使用（99m）锝（62GBq）和（18）氟（12GBq）源进行测试，测量其活度直至低于1MBq的值。计算实验和理论（99m）锝及（18）氟源活度之间的比率和偏差，随后进行比较。

结果

实验和理论（99m）锝及（18）氟源活度之间的平均偏差分别为0.56（±1.79）%和0.92（±1.19）%。用预校准用于测量（99m）锝和（18）氟的设备测量时，该设备指示的（99m）锝源活度之间的平均比率为3.42（±0.06），（18）氟源的该比率为3.39（±0.05），这些值在测量时间内被认为是恒定的。

结论

使用（99m）锝进行线性测试的结果与使用（18）氟源获得的结果相符，表明在剂量校准器线性测试中使用这两种放射性同位素都是可行的。这些信息连同（18）氟获取过程中涉及的高辐射暴露潜力和成本表明，在使用（18）氟的中心，（99m）锝是进行剂量校准器线性测试的首选元素，对该程序以及核医学服务质量均无损害。