2-氨基-7-膦酰庚酸对大鼠脑电图的影响。
Effects of 2-amino-7-phosphonoheptanoic acid on EEG of rats.
作者信息
Rostain J C, Wardley-Smith B, Meldrum B S
出版信息
Electroencephalogr Clin Neurophysiol. 1985 Apr;60(4):367-9. doi: 10.1016/0013-4694(85)90010-0.
PMID:2579803
Abstract
2-APH is an antagonist of excitation due to dicarboxylic amino acids and has a protective effect against several types of experimental seizures. We have studied its effect on EEG of rats. Following either intracerebroventricular or intraperitoneal administration of 2-APH produces slow waves of high voltage in central cortex. The anticonvulsant action of this drug may be related to altered activity in neurones of this area.
摘要
2-氨基嘌呤是二羧酸氨基酸引起的兴奋的拮抗剂，对几种类型的实验性癫痫发作具有保护作用。我们研究了它对大鼠脑电图的影响。经脑室或腹腔注射2-氨基嘌呤后，大脑中央皮质会产生高电压慢波。这种药物的抗惊厥作用可能与该区域神经元活动的改变有关。
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