Piredda S, Gale K
Eur J Pharmacol. 1986 Jan 14;120(1):115-8. doi: 10.1016/0014-2999(86)90649-7.
Microinjection of 2-amino-phosphonoheptanoic acid (2APH, 1 nmol), and antagonist for n-methyl-d-aspartate-sensitive receptors, into the deep prepiriform cortex (DPC) of the rat, prevented seizures induced by the intravenous administration of bicuculline. The GABA agonist, muscimol (39 pmol), injected into DPC produced a similar anticonvulsant effect. The DPC may therefore represent an important site of action for the anticonvulsant effects of GABA agonists and excitatory amino acid antagonists. Moreover, our data support the hypothesis that seizures induced by a deficiency in GABA transmission result, at least in part, from a relative overactivity of excitatory amino acid transmission in the DPC.
将N-甲基-D-天冬氨酸敏感受体拮抗剂2-氨基膦酰庚酸（2APH，1纳摩尔）微量注射到大鼠的深部梨状前皮质（DPC），可预防静脉注射荷包牡丹碱诱发的癫痫发作。向DPC注射GABA激动剂蝇蕈醇（39皮摩尔）产生了类似的抗惊厥作用。因此，DPC可能是GABA激动剂和兴奋性氨基酸拮抗剂抗惊厥作用的一个重要作用位点。此外，我们的数据支持这样的假说，即由GABA传递不足诱发的癫痫发作至少部分是由于DPC中兴奋性氨基酸传递相对过度活跃所致。
