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Conjugated Estrogens/Bazedoxifene (Duavee): A Novel Agent for the Treatment of Moderate-to-Severe Vasomotor Symptoms Associated With Menopause And the Prevention of Postmenopausal Osteoporosis.共轭雌激素/巴多昔芬（Duavee）：一种用于治疗与绝经相关的中重度血管舒缩症状及预防绝经后骨质疏松症的新型药物。
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Conjugated Estrogens/Bazedoxifene (Duavee) for Menopausal Symptoms.共轭雌激素/巴多昔芬（Duavee）用于治疗更年期症状。
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Bazedoxifene and bazedoxifene combined with conjugated estrogens for the management of postmenopausal osteoporosis.巴多昔芬及巴多昔芬与共轭雌激素联合用于绝经后骨质疏松症的治疗。
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Tissue-selective estrogen complexes for postmenopausal women.用于绝经后妇女的组织选择性雌激素复合物。
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Bazedoxifene/conjugated estrogens combination for the treatment of the vasomotor symptoms associated with menopause and for prevention of osteoporosis in postmenopausal women.巴多昔芬/共轭雌激素组合用于治疗绝经相关血管舒缩症状及预防绝经后女性骨质疏松症。
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Menopause-specific quality of life across varying menopausal populations with conjugated estrogens/bazedoxifene.不同绝经人群使用共轭雌激素/巴多昔芬后的绝经特异性生活质量。
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Effect of conjugated estrogens/bazedoxifene on postmenopausal bone loss: pooled analysis of two randomized trials.共轭雌激素/巴多昔芬对绝经后骨质流失的影响：两项随机试验的汇总分析。
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Conjugated estrogens/bazedoxifene (Duavee) for menopausal symptoms and prevention of osteoporosis.
Med Lett Drugs Ther. 2014 Apr 28;56(1441):33-4.

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Effects of conjugated estrogen and bazedoxifene on hemostasis and thrombosis in mice.共轭雌激素和巴多昔芬对小鼠止血和血栓形成的影响。
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Bazedoxifene-induced vasodilation and inhibition of vasoconstriction is significantly greater than estradiol.巴多昔芬诱导的血管舒张作用和抑制血管收缩作用明显大于雌二醇。
Menopause. 2019 Feb;26(2):172-181. doi: 10.1097/GME.0000000000001195.

本文引用的文献

1
Updated 2013 International Menopause Society recommendations on menopausal hormone therapy and preventive strategies for midlife health.2013年国际绝经学会关于绝经激素治疗及中年健康预防策略的更新建议。
Climacteric. 2013 Jun;16(3):316-37. doi: 10.3109/13697137.2013.795683.
2
Breast effects of bazedoxifene-conjugated estrogens: a randomized controlled trial.巴泽多昔芬结合雌激素对乳房的影响：一项随机对照试验。
Obstet Gynecol. 2013 May;121(5):959-968. doi: 10.1097/AOG.0b013e31828c5974.
3
Effects of bazedoxifene/conjugated estrogens on endometrial safety and bone in postmenopausal women.地屈孕酮/结合雌激素对绝经后妇女子宫内膜安全性和骨骼的影响。
Climacteric. 2013 Jun;16(3):338-46. doi: 10.3109/13697137.2012.717994. Epub 2012 Oct 5.
4
The 2012 hormone therapy position statement of: The North American Menopause Society.《北美绝经学会 2012 年激素治疗立场声明》。
Menopause. 2012 Mar;19(3):257-71. doi: 10.1097/gme.0b013e31824b970a.
5
American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of menopause.美国临床内分泌医师协会绝经诊断和治疗临床实践医学指南
Endocr Pract. 2011 Nov-Dec;17 Suppl 6:1-25. doi: 10.4158/ep.17.s6.1.
6
In vitro metabolism, permeability, and efflux of bazedoxifene in humans.在人体中，巴泽多昔芬的体外代谢、渗透性和外排。
Drug Metab Dispos. 2010 Sep;38(9):1471-9. doi: 10.1124/dmd.109.030999. Epub 2010 Jun 1.
7
A randomized, placebo- and active-controlled trial of bazedoxifene/conjugated estrogens for treatment of moderate to severe vulvar/vaginal atrophy in postmenopausal women.一项随机、安慰剂和阳性对照试验，评估巴多昔芬/结合雌激素治疗绝经后妇女中至重度外阴/阴道萎缩。
Menopause. 2010 Mar;17(2):281-9. doi: 10.1097/GME.0b013e3181b7c65f.
8
Endometrial effects of a tissue selective estrogen complex containing bazedoxifene/conjugated estrogens as a menopausal therapy.含有巴多昔芬/共轭雌激素的组织选择性雌激素复合物作为绝经疗法对子宫内膜的影响。
Fertil Steril. 2009 Sep;92(3):1018-1024. doi: 10.1016/j.fertnstert.2009.05.094. Epub 2009 Jul 26.
9
Relief of vasomotor symptoms with the tissue-selective estrogen complex containing bazedoxifene/conjugated estrogens: a randomized, controlled trial.含巴多昔芬/结合雌激素的组织选择性雌激素复合物缓解血管舒缩症状：一项随机对照试验。
Menopause. 2009 Nov-Dec;16(6):1116-24. doi: 10.1097/gme.0b013e3181a7df0d.
10
Bazedoxifene for the prevention of postmenopausal osteoporosis.巴多昔芬用于预防绝经后骨质疏松症。
Ther Clin Risk Manag. 2008 Dec;4(6):1229-42. doi: 10.2147/tcrm.s3476.

共轭雌激素/巴多昔芬（Duavee）：一种用于治疗与绝经相关的中重度血管舒缩症状及预防绝经后骨质疏松症的新型药物。

Conjugated Estrogens/Bazedoxifene (Duavee): A Novel Agent for the Treatment of Moderate-to-Severe Vasomotor Symptoms Associated With Menopause And the Prevention of Postmenopausal Osteoporosis.

作者信息

Goldberg Tamara, Fidler Brooke

出版信息

P T. 2015 Mar;40(3):178-82.

PMID:25798038
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4357350/
Abstract

Conjugated estrogens/bazedoxifene (Duavee): a novel agent for the treatment of moderate-to-severe vasomotor symptoms associated with menopause and the prevention of postmenopausal osteoporosis.

摘要

共轭雌激素/巴多昔芬（Duavee）：一种用于治疗与绝经相关的中重度血管舒缩症状及预防绝经后骨质疏松症的新型药物。