• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

And-1 O-GlcNAcylation regulates homologous recombination repair and radioresistance in colorectal cancer.

作者信息

Zhou Yuan, Zhang Yi, Peng Changmin, Li Zhuqing, Pei Huadong, Pei Haiping, Zhu Wenge

机构信息

Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China.

Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, USA.

出版信息

Clin Transl Med. 2022 Apr;12(4):e785. doi: 10.1002/ctm2.785.

DOI:10.1002/ctm2.785
PMID:35474639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9043118/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d089/9043118/79d01aefaf6c/CTM2-12-e785-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d089/9043118/d85941e9a45c/CTM2-12-e785-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d089/9043118/93d1f72f456c/CTM2-12-e785-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d089/9043118/c16ce183bf66/CTM2-12-e785-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d089/9043118/79d01aefaf6c/CTM2-12-e785-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d089/9043118/d85941e9a45c/CTM2-12-e785-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d089/9043118/93d1f72f456c/CTM2-12-e785-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d089/9043118/c16ce183bf66/CTM2-12-e785-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d089/9043118/79d01aefaf6c/CTM2-12-e785-g004.jpg

相似文献

1
And-1 O-GlcNAcylation regulates homologous recombination repair and radioresistance in colorectal cancer.And-1的O-连接N-乙酰葡糖胺化修饰调控结直肠癌中的同源重组修复及放射抗性。
Clin Transl Med. 2022 Apr;12(4):e785. doi: 10.1002/ctm2.785.
2
Homologous Recombination DNA Repair Gene Aberrations-Are We More Alike Than Different?
JAMA Netw Open. 2020 Oct 1;3(10):e2021717. doi: 10.1001/jamanetworkopen.2020.21717.
3
Genome-wide RNAi Screening Identifies RFC4 as a Factor That Mediates Radioresistance in Colorectal Cancer by Facilitating Nonhomologous End Joining Repair.全基因组 RNAi 筛选鉴定 RFC4 为通过促进非同源末端连接修复来介导结直肠癌放射抗性的因素。
Clin Cancer Res. 2019 Jul 15;25(14):4567-4579. doi: 10.1158/1078-0432.CCR-18-3735. Epub 2019 Apr 12.
4
DNA helicases in homologous recombination repair.DNA 解旋酶在同源重组修复中的作用。
Curr Opin Genet Dev. 2021 Dec;71:27-33. doi: 10.1016/j.gde.2021.06.009. Epub 2021 Jul 14.
5
5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair.5-氟尿嘧啶通过干扰同源重组修复使结直肠肿瘤细胞对双链DNA断裂敏感。
Oncotarget. 2015 May 20;6(14):12574-86. doi: 10.18632/oncotarget.3728.
6
The absence of the RecN protein suppresses the cellular defects of Deinococcus radiodurans irradiated cells devoid of the PprA protein by limiting recombinational repair of DNA lesions.RecN 蛋白的缺失通过限制 DNA 损伤的重组修复来抑制缺乏 PprA 蛋白的辐射处理的 Deinococcus radiodurans 细胞的细胞缺陷。
DNA Repair (Amst). 2019 Jan;73:144-154. doi: 10.1016/j.dnarep.2018.11.011. Epub 2018 Nov 28.
7
TOPORS-mediated RAD51 SUMOylation facilitates homologous recombination repair.TOPORS 介导的 RAD51 SUMOylation 促进同源重组修复。
Nucleic Acids Res. 2022 Feb 22;50(3):1501-1516. doi: 10.1093/nar/gkac009.
8
Depletion of Akt1 and Akt2 Impairs the Repair of Radiation-Induced DNA Double Strand Breaks via Homologous Recombination.Akt1 和 Akt2 的耗竭通过同源重组损伤辐射诱导的 DNA 双链断裂的修复。
Int J Mol Sci. 2019 Dec 14;20(24):6316. doi: 10.3390/ijms20246316.
9
Defects in homologous recombination repair behind the human diseases: FA and HBOC.人类疾病背后同源重组修复的缺陷:范可尼贫血和遗传性乳腺癌卵巢癌综合征
Endocr Relat Cancer. 2016 Oct;23(10):T19-37. doi: 10.1530/ERC-16-0221. Epub 2016 Aug 22.
10
miR-21-mediated Radioresistance Occurs via Promoting Repair of DNA Double Strand Breaks.微小RNA-21介导的放射抗性通过促进DNA双链断裂的修复而发生。
J Biol Chem. 2017 Feb 24;292(8):3531-3540. doi: 10.1074/jbc.M116.772392. Epub 2017 Jan 17.

引用本文的文献

1
DNA damage-induced YTHDC1 O-GlcNAcylation promotes homologous recombination by enhancing mA binding.DNA损伤诱导的YTHDC1 O-连接N-乙酰葡糖胺化通过增强mA结合促进同源重组。
Fundam Res. 2023 Jun 5;5(2):868-879. doi: 10.1016/j.fmre.2023.04.017. eCollection 2025 Mar.
2
Establishment and transcriptomic characteristics of radio-resistant meningioma cell lines.放射性抗性脑膜瘤细胞系的建立及其转录组特征
J Neurooncol. 2025 May;173(1):105-119. doi: 10.1007/s11060-025-04966-6. Epub 2025 Feb 28.
3
Systematic pan-cancer analysis reveals OGT and OGA as potential biomarkers for tumor microenvironment and therapeutic responses.

本文引用的文献

1
Discovery and characterization of potent And-1 inhibitors for cancer treatment.发现并表征用于癌症治疗的强效 And-1 抑制剂。
Clin Transl Med. 2021 Dec;11(12):e627. doi: 10.1002/ctm2.627.
2
O-GlcNAcylation Affects the Pathway Choice of DNA Double-Strand Break Repair.O-GlcNAcylation 影响 DNA 双链断裂修复的途径选择。
Int J Mol Sci. 2021 May 27;22(11):5715. doi: 10.3390/ijms22115715.
3
TTK inhibition radiosensitizes basal-like breast cancer through impaired homologous recombination.TTK 抑制通过损伤同源重组增强基底样乳腺癌的放射敏感性。
系统性泛癌分析揭示OGT和OGA作为肿瘤微环境及治疗反应的潜在生物标志物。
Genes Dis. 2023 Sep 9;11(4):101089. doi: 10.1016/j.gendis.2023.101089. eCollection 2024 Jul.
J Clin Invest. 2020 Feb 3;130(2):958-973. doi: 10.1172/JCI130435.
4
O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors.O-GlcNAcylation 增强双链断裂修复,促进癌细胞增殖,并防止辐照肿瘤治疗诱导的衰老。
Mol Cancer Res. 2019 Jun;17(6):1338-1350. doi: 10.1158/1541-7786.MCR-18-1025. Epub 2019 Mar 18.
5
Protein O-GlcNAcylation: emerging mechanisms and functions.蛋白质O-连接的N-乙酰葡糖胺糖基化:新出现的机制与功能
Nat Rev Mol Cell Biol. 2017 Jul;18(7):452-465. doi: 10.1038/nrm.2017.22. Epub 2017 May 10.
6
And-1 is required for homologous recombination repair by regulating DNA end resection.And-1通过调节DNA末端切除来参与同源重组修复。
Nucleic Acids Res. 2017 Mar 17;45(5):2531-2545. doi: 10.1093/nar/gkw1241.
7
And-1 coordinates with CtIP for efficient homologous recombination and DNA damage checkpoint maintenance.And-1与CtIP协同作用,以实现高效的同源重组和维持DNA损伤检查点。
Nucleic Acids Res. 2017 Mar 17;45(5):2516-2530. doi: 10.1093/nar/gkw1212.
8
Conjugated Estrogens/Bazedoxifene (Duavee): A Novel Agent for the Treatment of Moderate-to-Severe Vasomotor Symptoms Associated With Menopause And the Prevention of Postmenopausal Osteoporosis.共轭雌激素/巴多昔芬(Duavee):一种用于治疗与绝经相关的中重度血管舒缩症状及预防绝经后骨质疏松症的新型药物。
P T. 2015 Mar;40(3):178-82.
9
Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain.细胞核和细胞质蛋白的动态O-糖基化:人脑中性细胞质β-N-乙酰氨基葡萄糖苷酶的克隆与特性分析
J Biol Chem. 2001 Mar 30;276(13):9838-45. doi: 10.1074/jbc.M010420200. Epub 2001 Jan 8.
10
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells.XRCC3促进哺乳动物细胞中DNA损伤的同源定向修复。
Genes Dev. 1999 Oct 15;13(20):2633-8. doi: 10.1101/gad.13.20.2633.