Instituto Cajal (CSIC) Madrid, Spain ; Laboratorio Cajal de Circuitos Corticales (Centro de Tecnología Biomédica: UPM), and CIBERNED Madrid, Spain.
Front Neuroanat. 2015 Mar 5;9:14. doi: 10.3389/fnana.2015.00014. eCollection 2015.
Dendritic spines are key components of a variety of microcircuits and they represent the majority of postsynaptic targets of glutamatergic axon terminals in the brain. The present article will focus on the discovery of dendritic spines, which was possible thanks to the application of the Golgi technique to the study of the nervous system, and will also explore the early interpretation of these elements. This discovery represents an interesting chapter in the history of neuroscience as it shows us that progress in the study of the structure of the nervous system is based not only on the emergence of new techniques but also on our ability to exploit the methods already available and correctly interpret their microscopic images.
树突棘是各种微电路的关键组成部分，它们代表大脑中谷氨酸能轴突末梢的大多数突触后靶标。本文将重点介绍树突棘的发现，这得益于高尔基体技术在神经系统研究中的应用，并探讨对这些元素的早期解释。这一发现是神经科学史上一个有趣的篇章，因为它向我们表明，神经系统结构研究的进展不仅取决于新技术的出现，还取决于我们利用现有方法的能力和正确解释其微观图像的能力。
