Kennedy R H, Seifen E
Eur J Pharmacol. 1985 Jan 2;107(2):209-14. doi: 10.1016/0014-2999(85)90060-3.
The inotropic and chronotropic effects of BAY K-8644 were examined in isolated guinea pig atria. The compound increased both rate and contractile force. Sensitivity to the inotropic effect was enhanced by increasing stimulation frequency between 0.5 and 3.3 Hz. The maximum developed tension elicited by the agent was reduced at 3.3 Hz. At BAY K-8644 concentrations up of to 3 X 10(-5) M, no dysrhythmic effects or other toxic signs such as an increase in resting tension were observed. These results are consistent with the suggestion that BAY K-8644 acts as a partial 'calcium agonist'.
在离体豚鼠心房中研究了BAY K - 8644的变力性和变时性作用。该化合物可增加心率和收缩力。在0.5至3.3 Hz之间增加刺激频率可增强对变力作用的敏感性。在3.3 Hz时，该药物引起的最大张力降低。在BAY K - 8644浓度高达3×10(-5) M时，未观察到心律失常作用或其他毒性迹象，如静息张力增加。这些结果与BAY K - 8644作为部分“钙激动剂”的观点一致。
