Barrett K E, Tashof T L, Metcalfe D D
Eur J Pharmacol. 1985 Jan 2;107(2):279-81. doi: 10.1016/0014-2999(85)90071-8.
The effect of sulphasalazine on two mast cell populations and human peripheral leukocytes is reported. Sulphasalazine inhibited histamine release from mouse and rat mast cells, but it caused a potentiation of secretion in human peripheral leukocytes. The drug alone did not induce histamine release when administered without an anaphylactic stimulus. The results are discussed in terms of a possible mode of action of sulphasalazine in the treatment of inflammatory bowel disease.
报告了柳氮磺胺吡啶对两种肥大细胞群体和人外周血白细胞的作用。柳氮磺胺吡啶抑制小鼠和大鼠肥大细胞释放组胺，但它会增强人外周血白细胞的分泌。在没有过敏刺激的情况下给药时，该药物单独不会诱导组胺释放。根据柳氮磺胺吡啶在治疗炎症性肠病中的可能作用方式对结果进行了讨论。
