Lončar-Turukalo T, Vasić M, Tasić T, Mijatović G, Glumac S, Bajić D, Japunžić-Žigon N
Faculty of Technical Sciences, University of Novi Sad, Serbia.
Physiol Meas. 2015 Apr;36(4):727-39. doi: 10.1088/0967-3334/36/4/727. Epub 2015 Mar 23.
The clinical use of doxorubicin, an effective chemotherapeutic is hampered by the development of irreversible cardiotoxicity. Here we test time-frequency analysis of heart rate (HR) variability (HRV) for early detection of doxorubicin-induced cardiotoxicity. Experiments were conducted in adult male Wistar rats treated for 15 days with doxorubicin (DOXO, total dose 15 mg kg(-1), i.p.) or saline (CONT). DOXO rats exhibited cardiotoxicity confirmed by histological examination without developing heart failure as estimated by echocardiography. However, HR variability increase reflected subtle microscopic changes of cardiac toxicity in DOXO rats. The results recommend time-frequency analysis of HRV for early detection of doxorubicin-induced cardiomyopathy.
阿霉素是一种有效的化疗药物，但其临床应用因不可逆心脏毒性的发生而受到阻碍。在此，我们测试心率变异性（HRV）的时频分析用于早期检测阿霉素诱导的心脏毒性。实验在成年雄性Wistar大鼠中进行，用阿霉素（DOXO，总剂量15mg/kg，腹腔注射）或生理盐水（CONT）处理15天。DOXO大鼠表现出心脏毒性，经组织学检查证实，经超声心动图评估未发生心力衰竭。然而，HR变异性增加反映了DOXO大鼠心脏毒性的细微微观变化。结果表明HRV的时频分析可用于早期检测阿霉素诱导的心肌病。
