Te Mi, Zhao Ethan, Zheng Xingyue, Sun Qinjian, Qu Chuanqiang
Neurol Res. 2015 May;37(5):410-4. doi: 10.1179/1743132815Y.0000000028. Epub 2015 Mar 23.
As the ageing population continues to increase, the prevalence of age-related cognitive impairment has been on the rise. Mild cognitive impairment (MCI) is now widely recognised as the early stage of dementia. Mild cognitive impairment is closely associated with cerebral white matter lesions (WMLs), specifically in the case of leukoaraiosis (LA). A previous diffusion tensor imaging (DTI) has demonstrated that white matter changes might damage cognitive function in LA patients, and the cognitive function might decrease with the deterioration of LA. Through consulting and analysing documents, we found that both of them share similarities in risk factors, pathogenesis, pathological changes, and imaging manifestations. The main characteristics of LA patients with MCI (LACI) are the early and apparent manifestations of delayed memory, attention, impaired executive function, and close association with dementia. This analysis of LACI may contribute to an early diagnosis of LACI and provide possible treatment for LACI.
随着老龄化人口持续增加，与年龄相关的认知障碍患病率一直在上升。轻度认知障碍（MCI）目前被广泛认为是痴呆症的早期阶段。轻度认知障碍与脑白质病变（WMLs）密切相关，尤其是在脑白质疏松症（LA）的情况下。先前的扩散张量成像（DTI）表明，白质变化可能损害LA患者的认知功能，并且认知功能可能随着LA的恶化而下降。通过查阅和分析文献，我们发现它们在危险因素、发病机制、病理变化和影像学表现方面存在相似之处。伴有MCI的LA患者（LACI）的主要特征是记忆延迟、注意力、执行功能受损的早期和明显表现，以及与痴呆症的密切关联。对LACI的这种分析可能有助于LACI的早期诊断，并为LACI提供可能的治疗方法。
