Mohty M, Malard F, Abecassis M, Aerts E, Alaskar A S, Aljurf M, Arat M, Bader P, Baron F, Bazarbachi A, Blaise D, Ciceri F, Corbacioglu S, Dalle J-H, Duarte R F, Fukuda T, Huynh A, Masszi T, Michallet M, Nagler A, NiChonghaile M, Pagluica T, Peters C, Petersen F B, Richardson P G, Ruutu T, Savani B N, Wallhult E, Yakoub-Agha I, Carreras E
Hematology department, Hôpital Saint-Antoine, and Université Pierre & Marie Curie, Paris, France.
Inst Portugues Oncologia, Lisboa, Portugal.
Bone Marrow Transplant. 2015 Jun;50(6):781-9. doi: 10.1038/bmt.2015.52. Epub 2015 Mar 23.
Sinusoidal obstruction syndrome or veno-occlusive disease (SOS/VOD) is a potentially life-threatening complication of hematopoietic SCT (HSCT). This review aims to highlight, on behalf of the European Society for Blood and Marrow Transplantation, the current knowledge on SOS/VOD pathophysiology, risk factors, diagnosis and treatments. Our perspectives on SOS/VOD are (i) to accurately identify its risk factors; (ii) to define new criteria for its diagnosis; (iii) to search for SOS/VOD biomarkers and (iv) to propose prospective studies evaluating SOS/VOD prevention and treatment in adults and children.
窦性阻塞综合征或静脉闭塞性疾病（SOS/VOD）是造血干细胞移植（HSCT）一种潜在的危及生命的并发症。本综述旨在代表欧洲血液和骨髓移植学会，强调目前关于SOS/VOD病理生理学、危险因素、诊断和治疗的知识。我们对SOS/VOD的观点是：（i）准确识别其危险因素；（ii）定义其诊断的新标准；（iii）寻找SOS/VOD生物标志物；（iv）提出评估成人和儿童SOS/VOD预防和治疗的前瞻性研究。
