Anwar Md Rajib, Camarda Kyle V, Kieweg Sarah L
Bioengineering Graduate Program, The University of Kansas, USA.
Bioengineering Graduate Program, The University of Kansas, USA; Department of Chemical & Petroleum Engineering, The University of Kansas, USA.
J Biomech. 2015 Jun 25;48(9):1625-30. doi: 10.1016/j.jbiomech.2015.01.049. Epub 2015 Feb 17.
Topically applied microbicide gels can provide a self-administered and effective strategy to prevent sexually transmitted infections (STIs). We have investigated the interplay between vaginal tissue elasticity and the yield-stress of non-Newtonian fluids during microbicide deployment. We have developed a mathematical model of tissue deformation driven spreading of microbicidal gels based on thin film lubrication approximation and demonstrated the effect of tissue elasticity and fluid yield-stress on the spreading dynamics. Our results show that both elasticity of tissue and yield-stress rheology of gel are strong determinants of the coating behavior. An optimization framework has been demonstrated which leverages the flow dynamics of yield-stress fluid during deployment to maximize retention while reaching target coating length for a given tissue elasticity.
局部应用的杀微生物剂凝胶可为预防性传播感染（STIs）提供一种自我给药且有效的策略。我们研究了在杀微生物剂部署过程中阴道组织弹性与非牛顿流体屈服应力之间的相互作用。我们基于薄膜润滑近似开发了一种杀微生物凝胶组织变形驱动扩散的数学模型，并证明了组织弹性和流体屈服应力对扩散动力学的影响。我们的结果表明，组织弹性和凝胶的屈服应力流变学都是涂层行为的重要决定因素。已经展示了一个优化框架，该框架利用部署过程中屈服应力流体的流动动力学，在给定组织弹性下达到目标涂层长度的同时最大化保留率。
