Kusano S, Ohta A
Invest Radiol. 1985 Jan-Feb;20(1):36-41.
Selective renal artery embolization with absolute ethanol was performed without balloon occlusion in a series of 11 healthy mongrel dogs. Electrocardiogram, blood ethanol level, heart rate, and blood pressure of the aorta and pulmonary artery were monitored. Ventricular extrasystoles and/or ventricular fibrillation occurred in six of the 11 dogs, to which absolute ethanol in doses ranging from 0.09 to 0.40 ml/kg was administered. In three of these six animals, the electrocardiograms showed only ventricular extrasystoles after intra-arterial bolus injection of absolute ethanol at doses of less than 0.15 ml/kg and subsequent recovery to a normal sinus rhythm. Ventricular fibrillation subsequent to ventricular extrasystoles immediately after intra-arterial injection of absolute ethanol at doses of more than 0.18 ml/kg occurred in three. In five of eight dogs that survived after alcohol injection in this series, a severe hypertensive response was observed. Absolute ethanol has the potential hazard of causing ventricular arrhythmia. Thus, careful observations should be undertaken in clinical therapeutic application of this agent, particularly in the absence of balloon occlusion, absolute ethanol should never be used without monitoring the electrocardiogram.
在11只健康杂种犬中，未进行球囊闭塞，采用无水乙醇进行选择性肾动脉栓塞。监测心电图、血液乙醇水平、心率以及主动脉和肺动脉的血压。11只犬中有6只出现室性期前收缩和/或心室颤动，给予剂量为0.09至0.40 ml/kg的无水乙醇。在这6只动物中的3只，动脉内推注剂量小于0.15 ml/kg的无水乙醇后，心电图仅显示室性期前收缩，随后恢复为正常窦性心律。3只犬在动脉内注射剂量大于0.18 ml/kg的无水乙醇后，室性期前收缩后立即出现心室颤动。在该系列中注射乙醇后存活的8只犬中的5只，观察到严重的高血压反应。无水乙醇有导致室性心律失常的潜在风险。因此，在该药物的临床治疗应用中应进行仔细观察，特别是在没有球囊闭塞的情况下，在未监测心电图时绝不应使用无水乙醇。
