Lee Jeong-Jin, Do Young-Soo, Kim Jie-Ae
Department of Anesthesiology and Pain Medicine, Sungkyunkwan University School of Medicine, Samsung Seoul Hospital, 50 Ilwon-dong, Kangnam-gu, Seoul 135-710, Korea.
J Korean Med Sci. 2004 Feb;19(1):51-4. doi: 10.3346/jkms.2004.19.1.51.
We analyzed the effects of several factors on the serum ethanol levels after alcohol sclerotherapy in the arteriovenous malformations (AVMs) retrospectively. Blood ethanol level, amounts of given alcohol, location of lesions, methods of flow control, and Doppler resistive index (RI) were analyzed. The results of linear regression analysis showed that the amount of alcohol administered was the predictor of serum ethanol level (r2=0.75, p<0.001). The average amount of injected alcohol was 0.89 mL/kg in the patients with the serum levels above the legal intoxication level (>80 mg/dL). Location of the lesions was not related with the serum ethanol level (p=0.643), and other variables such as forms of flow control and RI were not related to the serum ethanol level after controlling for injected amounts of alcohol (analysis of covariance). It is recommended to keep an eye on the possibility of intoxication when using the amounts of alcohol exceeding 0.89 mL/kg in the sclerotherapy of AVMs.
我们回顾性分析了多种因素对动静脉畸形（AVM）酒精硬化治疗后血清乙醇水平的影响。分析了血液乙醇水平、酒精注入量、病变位置、血流控制方法以及多普勒阻力指数（RI）。线性回归分析结果显示，酒精注入量是血清乙醇水平的预测指标（r2 = 0.75，p < 0.001）。血清水平高于法定中毒水平（>80 mg/dL）的患者，平均酒精注入量为0.89 mL/kg。病变位置与血清乙醇水平无关（p = 0.643），在控制酒精注入量后（协方差分析），其他变量如血流控制形式和RI与血清乙醇水平无关。在AVM硬化治疗中，当酒精用量超过0.89 mL/kg时，建议留意中毒的可能性。
