铑（III）催化的芳香羧酸脱羧邻位杂芳基化反应，该反应使用羧酸作为无痕导向基团。
Rh(III)-catalyzed decarboxylative ortho-heteroarylation of aromatic carboxylic acids by using the carboxylic acid as a traceless directing group.
作者信息
Qin Xurong, Sun Denan, You Qiulin, Cheng Yangyang, Lan Jingbo, You Jingsong
机构信息
†Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, China.
‡College of Pharmaceutical Science, Southwest University, 2 Tiansheng Road, Chongqing 400716, China.
出版信息
Org Lett. 2015 Apr 3;17(7):1762-5. doi: 10.1021/acs.orglett.5b00532. Epub 2015 Mar 23.
Highly selective decarboxylative ortho-heteroarylation of aromatic carboxylic acids with various heteroarenes has been developed through Rh(III)-catalyzed two-fold C-H activation, which exhibits a wide substrate scope of both aromatic carboxylic acids and heteroarenes. The use of naturally occurring carboxylic acid as the directing group avoids troublesome extra steps for installation and removal of an external directing group.
通过铑（III）催化的双重C-H活化反应，实现了芳香羧酸与各种杂芳烃的高选择性脱羧邻位杂芳基化反应，该反应对芳香羧酸和杂芳烃均具有广泛的底物范围。使用天然存在的羧酸作为导向基团，避免了安装和去除外部导向基团的麻烦额外步骤。
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