University of Rochester , Rochester, New York 14627-0216, United States.
Org Lett. 2016 Oct 21;18(20):5432-5435. doi: 10.1021/acs.orglett.6b02862. Epub 2016 Oct 13.
Ruthenium ligated to tricyclohexylphosphine or di-tert-butylbipyridine catalyzes the arylation of carboxylic acids with diverse aryl halides (iodide, bromide, and triflate; aryl and heteroaryl). In addition, arylations with 2-iodophenol formed benzochromenones, carboxylate was shown to be a stronger donor than an amide, and the arylation of a pyridine carboxylate was demonstrated. Stoichiometric studies demonstrated that the added ligand is required for reaction with the electrophile but not the C-H bond.
钌与三环己基膦或二叔丁基联吡啶配位，可催化羧酸与各种芳基卤化物（碘化物、溴化物和三氟甲磺酸酯；芳基和杂芳基）的芳基化反应。此外，用 2-碘苯酚进行的芳基化反应形成苯并色烯酮，证明羧酸盐是比酰胺更强的给体，并且还证明了吡啶羧酸酯的芳基化反应。化学计量研究表明，添加的配体是与亲电试剂反应所必需的，但不是与 C-H 键反应所必需的。
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