Matin Rubeta
Churchill Hospital, Oxford, UK.
BMJ Clin Evid. 2015 Mar 20;2015:1717.
Vitiligo is an acquired skin disorder characterised by white (depigmented) patches in the skin, due to the loss of functioning melanocytes. The extent and distribution of vitiligo often changes during the course of a person's lifetime and its progression is unpredictable.
We conducted a systematic review and aimed to answer the following clinical question: What are the effects of surgical interventions for vitiligo in adults and in children? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2014 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
We found four studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
In this systematic review we present information relating to the effectiveness and safety of the following interventions: blister grafts, cultured cellular transplantation, non-cultured cellular transplantation, punch/mini grafts, and split thickness skin grafts.
白癜风是一种后天性皮肤疾病，其特征为皮肤出现白色（色素脱失）斑块，这是由于功能性黑素细胞缺失所致。白癜风的范围和分布在人的一生中常常会发生变化，其进展不可预测。
我们进行了一项系统评价，旨在回答以下临床问题：手术干预对成人和儿童白癜风有何影响？我们检索了：截至2014年4月的医学期刊数据库（Medline）、荷兰医学文摘数据库（Embase）、考克兰图书馆以及其他重要数据库（临床证据综述会定期更新，请查看我们的网站获取本综述的最新版本）。我们纳入了来自美国食品药品监督管理局（FDA）和英国药品及医疗产品监管局（MHRA）等相关组织的危害警示。
我们发现四项研究符合我们的纳入标准。我们对干预措施的证据质量进行了GRADE评估。
在本系统评价中，我们提供了有关以下干预措施有效性和安全性的信息：水疱移植、培养细胞移植、非培养细胞移植、钻孔/微型移植以及中厚皮片移植。
