National Center for Vitiligo, Psoriasis, PO Box 300320, Riyadh, 11372, Saudi Arabia; Wimpole Aesthetic Centre, 48 Wimpole Street, London, W1G 8SF, U.K.
Br J Dermatol. 2013 Oct;169 Suppl 3:57-66. doi: 10.1111/bjd.12532.
Vitiligo is a disfiguring disease, characterized frequently by the presence of de-pigmented macules and/or patches. Traditional therapies are essentially medical and are most preferred by dermatologists. Surgical therapies, however, are amongst the most effective interventions for vitiligo but are limited by their invasive nature, as well as the training and expertise needed to perform specific procedures.
To assess the evidence for the effectiveness, safety and applicability of the various surgical methods in the treatment of vitiligo.
For this systematic review of vitiligo surgical therapies, our searches included: PubMed, MEDLINE and Cochrane databases.
We reviewed research studies reporting on split thickness skin grafts (STSG), punch/mini-graft, blister roof grafting, cultured and non-cultured cellular transplantation (MKTP). While all methods vary in their repigmentation outcomes, STSG is found to have the highest repigmentation success rate. Overall, post-operative complications included milia, scarring, cobblestone appearance or hyperpigmentation of treated areas.
This review highlights the need for more randomized controlled trials in this field, underpinned by a more standardized objective approach to the assessment of repigmentation following surgical interventions.
白癜风是一种影响容貌的疾病，其特征通常是出现色素脱失的斑片和/或斑块。传统疗法主要是医学疗法，也是皮肤科医生最常采用的疗法。然而，手术疗法是治疗白癜风最有效的干预措施之一，但由于其具有侵袭性，以及实施特定手术所需的培训和专业知识，其应用受到限制。
评估各种手术方法治疗白癜风的有效性、安全性和适用性的证据。
为了对白癜风手术疗法进行系统评价，我们的检索包括：PubMed、MEDLINE 和 Cochrane 数据库。
我们综述了关于表皮片移植术（STSG）、打孔/微型移植术、水疱顶移植术、培养和非培养细胞移植术（MKTP）的研究报告。虽然所有方法在复色效果上有所不同，但 STSG 被发现具有最高的复色成功率。总体而言，术后并发症包括粟粒疹、瘢痕、鹅卵石样外观或治疗区域的色素沉着过度。
本综述强调了在该领域需要更多的随机对照试验，并需要采用更标准化的客观方法来评估手术干预后的复色情况。
