丙戊酸对小鼠脑内5-羟色胺代谢的影响。
Effect of valproic acid on 5-hydroxytryptamine turnover in mouse brain.
作者信息
Whitton P S, Oresković D, Jernej B, Bulat M
出版信息
J Pharm Pharmacol. 1985 Mar;37(3):199-200. doi: 10.1111/j.2042-7158.1985.tb05040.x.
Abstract
The effect of the antiepileptic drug valproic acid (di-n-propylacetic acid, 200 mg kg-1) on brain 5-hydroxytryptamine (5-HT) synthesis during monoamine oxidase inhibition by pargyline hydrochloride (120 mg kg-1) was studied in mice. Valproic acid increased 5-HT synthesis and elevated 5-hydroxyindoleacetic acid level in brain indicating that turnover of 5-HT is increased. The possible significance of this effect in relation to anticonvulsant action of valproic acid is discussed.
摘要
在小鼠中研究了抗癫痫药物丙戊酸（二正丙基乙酸，200毫克/千克）对盐酸帕吉林（120毫克/千克）抑制单胺氧化酶期间脑5-羟色胺（5-HT）合成的影响。丙戊酸增加了脑内5-HT的合成并提高了5-羟吲哚乙酸水平，表明5-HT的更新增加。讨论了这种作用与丙戊酸抗惊厥作用相关的可能意义。
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