Fuertes Miguel, Pérez Valentín, Benavides Julio, González-Lanza M Camino, Mezo Mercedes, González-Warleta Marta, Giráldez Francisco Javier, Fernández Miguel, Manga-González M Yolanda, Ferreras M Carmen
Instituto de Ganadería de Montaña CSIC-ULE, Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24071 León, Spain.
Centro de Investigaciones Agrarias de Mabegondo-INGACAL, Xunta de Galicia, Carretera Betanzos-Mesón do Vento, km 7, 15318 Abegondo, A Coruña, Spain.
Vet Parasitol. 2015 Apr 30;209(3-4):188-96. doi: 10.1016/j.vetpar.2015.02.034. Epub 2015 Mar 11.
Local host response and parasite distribution were studied in the forestomachs, abomasum, duodenum and regional lymph nodes of cattle suffering from bovine paramphistomosis. The parasites were found attached, by its ventral sucker, to small conical papillae of the rumen and reticulum. Affected papillae, showed morphological changes denoted by very narrow stalks and expanded heads. Histologically, these changes were characterized by epithelial acanthosis-hyperkeratosis of the epithelium. Infiltration of inflammatory cells was often related with the epithelial changes, although it was also found in the duodenal mucosa and submucosa. These cells were arranged as aggregates or follicles but sparse infiltration of eosinophils, globule leukocytes, mast cells or macrophages was also observed in the lamina propria. Tissue damage and inflammatory reaction were more severe in the ruminal atrium, where the largest number of flukes and affected papillae were observed. In contrast, lesions in the ruminal dorsal sac were absent or mild. Statistical correlation between lesion severity and parasite burden was confirmed.
对患有牛双腔吸虫病的牛的前胃、皱胃、十二指肠和局部淋巴结的局部宿主反应及寄生虫分布进行了研究。发现寄生虫通过其腹吸盘附着于瘤胃和网胃的小圆锥形乳头。受影响的乳头呈现出形态学变化，表现为非常狭窄的柄和扩大的头部。组织学上，这些变化的特征是上皮棘皮症 - 上皮过度角化。炎症细胞浸润常与上皮变化有关，尽管在十二指肠黏膜和黏膜下层也有发现。这些细胞呈聚集或滤泡状排列，但在固有层中也观察到嗜酸性粒细胞、球状白细胞、肥大细胞或巨噬细胞的稀疏浸润。瘤胃前庭的组织损伤和炎症反应更严重，在那里观察到的吸虫和受影响乳头数量最多。相比之下，瘤胃背囊的病变不存在或很轻微。病变严重程度与寄生虫负荷之间的统计相关性得到证实。
