Elliott J M, West M J, Chalmers J
J Cardiovasc Pharmacol. 1985 Jan-Feb;7(1):6-11. doi: 10.1097/00005344-198501000-00002.
The effects of vasopressin on heart rate and on the baroreceptor-heart period reflex were assessed during graded intravenous infusions of arginine vasopressin. Infusions which elevated plasma arginine vasopressin to 200 pg/ml had no effect on blood pressure, but induced a fall in heart rate and cardiac output and an increase in peripheral resistance. These effects were unaltered by vagal blockade with methylscopolamine and cardiac sympathetic blockade with propranolol but were prevented by pretreatment with a specific vascular antagonist to vasopressin, d(CH2)5Tyr(Me)AVP. Baroreflex control of heart rate was studied during vasopressin infusion by monitoring the heart period responses to graded changes in mean arterial blood pressure produced by inflation of balloon occluders around the abdominal aorta and thoracic vena cava. Elevation of plasma arginine vasopressin to 50 pg/ml and 200 pg/ml had no significant effect on the slope or sensitivity of the baroreceptor-heart period reflex but increased the maximum bradycardia elicited in response to large increases in blood pressure. We conclude that at physiological levels, arginine vasopressin has a direct cardiodepressant action that is not dependent on cardiac vagal or sympathetic activity. Our results indicate that arginine vasopressin increases the maximum bradycardia that can be elicited through baroreceptor reflexes but does not alter the slope relating change in heart rate to change in blood pressure.
在静脉内逐步输注精氨酸加压素期间，评估了加压素对心率和压力感受器 - 心脏周期反射的影响。将血浆精氨酸加压素升高至200 pg/ml的输注对血压无影响，但会导致心率和心输出量下降以及外周阻力增加。这些效应不受甲基东莨菪碱迷走神经阻滞和普萘洛尔心脏交感神经阻滞的影响，但可被一种特异性血管加压素拮抗剂d(CH2)5Tyr(Me)AVP预处理所阻止。在输注加压素期间，通过监测对围绕腹主动脉和胸段腔静脉的球囊封堵器充气所产生的平均动脉血压分级变化的心脏周期反应，研究了压力反射对心率的控制。将血浆精氨酸加压素升高至50 pg/ml和200 pg/ml对压力感受器 - 心脏周期反射的斜率或敏感性无显著影响，但增加了对血压大幅升高所引发的最大心动过缓。我们得出结论，在生理水平下，精氨酸加压素具有直接的心脏抑制作用，该作用不依赖于心脏迷走神经或交感神经活动。我们的结果表明，精氨酸加压素增加了通过压力感受器反射可引发的最大心动过缓，但不改变心率变化与血压变化之间的斜率关系。
