Story Lisa, Sankaran Srividhya, Mullins Edward, Tan Su, Russell Glynn, Kumar Sailesh, Kyle Pippa
Fetal Medicine Unit, St Thomas's Hospital, Lambeth Palace Road, London SE1 7EH, UK.
Fetal Medicine Unit, St Thomas's Hospital, Lambeth Palace Road, London SE1 7EH, UK.
Eur J Obstet Gynecol Reprod Biol. 2015 May;188:100-3. doi: 10.1016/j.ejogrb.2015.02.005. Epub 2015 Feb 16.
Counselling women where severe growth abnormalities are detected early in the pregnancy is often difficult due to a paucity of outcome data of this specific subset of early onset disease. This study therefore aimed to assess the outcome of pregnancies where an estimated fetal weight less than the third centile were detected prior to 24 weeks gestation.
A retrospective study in two London teaching hospitals, over an eight year period was performed, analysing all pregnancies with an ultrasound estimated fetal weight less than the third centile prior to 24 weeks gestation. Outcome data: intrauterine death, neonatal death, survival to discharge, gestation at delivery and birthweight were collected.
Out of 20 pregnancies included in the analysis, six died in utero, two died in the neonatal period and 12 (60%) survived until discharge. Of the livebirths, 67% delivered preterm and 100% percent of livebirths were delivered by Caesarean Section.
When severe growth abnormalities were detected before 24 weeks, more than half of pregnancies resulted in survival to neonatal discharge. There was an increased incidence of preterm delivery, caesarean section and neonatal unit admission. This information is useful in counselling parents.
由于缺乏早发性疾病这一特定亚组的结局数据，在孕期早期检测到严重生长异常时对孕妇进行咨询往往很困难。因此，本研究旨在评估在妊娠24周前检测到估计胎儿体重低于第三百分位数的妊娠结局。
在两家伦敦教学医院进行了一项为期八年的回顾性研究，分析了所有在妊娠24周前超声估计胎儿体重低于第三百分位数的妊娠。收集结局数据：宫内死亡、新生儿死亡、存活至出院、分娩孕周和出生体重。
在纳入分析的20例妊娠中，6例死于宫内，2例死于新生儿期，12例（60%）存活至出院。在活产儿中，67%为早产，100%的活产儿通过剖宫产分娩。
在24周前检测到严重生长异常时，超过一半的妊娠可存活至新生儿出院。早产、剖宫产和新生儿病房入院的发生率增加。这些信息有助于为父母提供咨询。
