掷出基因骰子：耐药性基底细胞癌中的中性和平滑异常的有害突变 - Suppr

Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma.

作者信息

Atwood Scott X, Sarin Kavita Y, Li Jiang R, Yao Catherine Y, Urman Nicole M, Chang Anne Lynn S, Tang Jean Y, Oro Anthony E

机构信息

Department of Dermatology and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.

出版信息

J Invest Dermatol. 2015 Aug;135(8):2138-2141. doi: 10.1038/jid.2015.115. Epub 2015 Mar 24.

DOI:10.1038/jid.2015.115

PMID:25801792

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4504757/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e9/4504757/2e54d682f8c5/nihms674126f1.jpg

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Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma.掷出基因骰子：耐药性基底细胞癌中的中性和平滑异常的有害突变

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本文引用的文献

Smoothened variants explain the majority of drug resistance in basal cell carcinoma.平滑蛋白变体解释了基底细胞癌中大部分的耐药性。

Cancer Cell. 2015 Mar 9;27(3):342-53. doi: 10.1016/j.ccell.2015.02.002.

Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma.皮肤鳞状细胞癌中动粒基因KNSTRN的复发性点突变。

Nat Genet. 2014 Oct;46(10):1060-2. doi: 10.1038/ng.3091. Epub 2014 Sep 7.

Advanced treatment for basal cell carcinomas.基底细胞癌的先进治疗方法。

Cold Spring Harb Perspect Med. 2014 Jul 1;4(7):a013581. doi: 10.1101/cshperspect.a013581.

Identification of recurrent SMO and BRAF mutations in ameloblastomas.成釉细胞瘤中复发性SMO和BRAF突变的鉴定。

Nat Genet. 2014 Jul;46(7):722-5. doi: 10.1038/ng.2986. Epub 2014 May 25.

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Cancer Cell. 2014 Mar 17;25(3):393-405. doi: 10.1016/j.ccr.2014.02.004.

Signatures of mutational processes in human cancer.人类癌症中的突变过程特征。

Nature. 2013 Aug 22;500(7463):415-21. doi: 10.1038/nature12477. Epub 2013 Aug 14.

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Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma.

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