Department of Dermatology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.
Bengbu Medical College, Bengbu, China.
Front Public Health. 2021 Jul 22;9:666528. doi: 10.3389/fpubh.2021.666528. eCollection 2021.
Ultraviolet radiation (UVR) is a known carcinogen participated for the development of skin cancers. Solar UVR exposure, particularly ultraviolet B (UVB), is the mostly significant environmental risk factor for the occurrence and progress of basal cell carcinoma(BCC). Both cumulative and intermittent high-grade UVR exposure could promote the uncontrolled replication of skin cells. There are also exsiting other contributing environmental factors that combine with the UVR exposure to promote the development of BCC. DNA damage in formation of skin cancers is considered to be a result of UVR toxicity. It is UVR that could activate a series of oncogenes simultaneously inactivating tumor suppressor genes and aberrant proliferation and survival of keratinocytes that repair these damages. Furthermore, mounting evidence demonstrates that inflammatory responses of immune cells in the tumor microenvironment plays crucial role in the skin tumorigenesis as well. In this chapter, we will follow the function of UVR in the onset and development of BCC. We describe the factors that influence BCC induced by UVR, and also review the recent advances of pathogenesis of BCC induced by UVR from the genetic and inflammatory aspects.
紫外线辐射（UVR）是一种已知的致癌物质，参与了皮肤癌的发生。太阳 UVR 暴露，特别是紫外线 B（UVB），是基底细胞癌（BCC）发生和进展的最重要的环境危险因素。累积和间歇性的高强度 UVR 暴露可促进皮肤细胞的失控复制。还有其他一些环境因素与 UVR 暴露一起促进 BCC 的发展。皮肤癌中 DNA 损伤的形成被认为是 UVR 毒性的结果。正是 UVR 同时激活了一系列癌基因，同时使肿瘤抑制基因失活，并使修复这些损伤的角质形成细胞异常增殖和存活。此外，越来越多的证据表明，肿瘤微环境中免疫细胞的炎症反应在皮肤肿瘤发生中也起着至关重要的作用。在这一章中，我们将探讨 UVR 在 BCC 发病和发展中的作用。我们描述了影响 UVR 诱导的 BCC 的因素，并从遗传和炎症方面综述了 UVR 诱导的 BCC 发病机制的最新进展。
