Protasio Maria I B, da Silva João P L, Arias-Carrión Oscar, Nardi Antonio E, Machado Sergio, Cruz Marcelo S
Program of Alcohol and Drugs, Institute of Psychiatry of Federal University of Rio de Janeiro, Rua do Oriente, 314/apt 401 CEP 20240-130. Rio de Janeiro, RJ, Brazil.
CNS Neurol Disord Drug Targets. 2015;14(3):331-40. doi: 10.2174/1871527314666150318114043.
Compulsions, like pathological gambling, binge-eating disorder, alcohol, tobacco or cocaine abuse and compulsive shopping have similar neurophysiological processing. This study aimed to examine the efficacy of repetitive transcranial magnetic stimulation (rTMS) in improving patient control over compulsive behavior. The rTMS modulatory role in cortical mesolimbic pathways possibly implies improvement of the inhibitory control system and compulsive consumption drive. Thus, craving reduction would be a component for control achievement. Within this context, 17 studies were found. Most studies applied rTMS over the left dorsolateral prefrontal cortex. Craving reduction was observed in 10 studies and was associated with improved control of compulsion in two of them. In one study reduction in consumption was found without reduction in craving. In addition, improvement in decision making was found in one study.
强迫行为，如病态赌博、暴饮暴食症、酒精、烟草或可卡因滥用以及强迫性购物，具有相似的神经生理过程。本研究旨在探讨重复经颅磁刺激（rTMS）在改善患者对强迫行为控制方面的疗效。rTMS在皮质中脑边缘通路中的调节作用可能意味着抑制控制系统和强迫性消费驱动力的改善。因此，减少渴望将是实现控制的一个组成部分。在此背景下，共找到17项研究。大多数研究将rTMS应用于左侧背外侧前额叶皮层。10项研究观察到渴望减少，其中两项研究发现这与强迫行为控制的改善有关。在一项研究中，发现消费减少但渴望未减少。此外，一项研究发现决策能力有所改善。
