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类风湿关节炎对中国患者工作能力的影响:一项横断面研究。

The impact of rheumatoid arthritis on work capacity in Chinese patients: a cross-sectional study.

机构信息

Department of Rheumatology and Immunology, People's Hospital, Peking University Health Science Center.

Department of Rheumatology and Immunology, Peking University Shougang Hospital.

出版信息

Rheumatology (Oxford). 2015 Aug;54(8):1478-87. doi: 10.1093/rheumatology/kev014. Epub 2015 Mar 22.

DOI:10.1093/rheumatology/kev014
PMID:25802400
Abstract

OBJECTIVE

To evaluate the impact of RA on work capacity and identify factors related to work capacity impairment in patients with RA.

METHODS

A cross-sectional multicentre study was performed in 21 tertiary care hospitals across China. A consecutive sample of 846 patients with RA was recruited, of which 589 patients of working age at disease onset constituted the study population. Information on the socio-demographic, clinical, working and financial conditions of the patients was collected. Logistic regression analyses were used to identify factors associated with work capacity impairment.

RESULTS

The rate of work capacity impairment was 48.0% in RA patients with a mean disease duration of 60 months (interquartile range 14-134 months), including 11.7% leaving the labour force early, 33.6% working reduced hours and 2.7% changing job. Multivariable logistic regression analysis showed that reduced working hours was significantly related to current smoking [odds ratio (OR) 2.07 (95% CI 1.08, 3.97)], no insurance [OR 1.94 (95% CI 1.20, 3.12)], in manual labour [OR 2.66 (95% CI 1.68, 4.20)] and higher HAQ score [OR 2.22 (95% CI 1.36, 3.60)]. There was an association of current smoking [OR 3.75 (95% CI 1.54, 9.15)], in manual labour [OR 2.33 (95% CI 1.17, 4.64)], longer disease duration [OR 1.01 (95% CI 1.00, 1.01)] and lower BMI [OR 0.90 (95% CI 0.82, 0.99)] with leaving the labour force early.

CONCLUSION

There is a substantial impact of RA on the work capacity of patients in China. Social-demographic, disease- and work-related factors are all associated with work capacity impairment.

摘要

目的

评估类风湿关节炎(RA)对工作能力的影响,并确定与 RA 患者工作能力受损相关的因素。

方法

在中国 21 家三级护理医院进行了一项横断面多中心研究。共招募了 846 例 RA 连续样本患者,其中发病时处于工作年龄的 589 例患者构成了研究人群。收集了患者的社会人口统计学、临床、工作和财务状况信息。采用逻辑回归分析来确定与工作能力受损相关的因素。

结果

在平均病程 60 个月(四分位间距 14-134 个月)的 RA 患者中,工作能力受损的发生率为 48.0%,包括 11.7%提前离开劳动力市场、33.6%工作时间减少和 2.7%换工作。多变量逻辑回归分析显示,工作时间减少与当前吸烟[比值比(OR)2.07(95%可信区间 1.08,3.97)]、无保险[OR 1.94(95%可信区间 1.20,3.12)]、从事体力劳动[OR 2.66(95%可信区间 1.68,4.20)]和较高的健康评估问卷(HAQ)评分[OR 2.22(95%可信区间 1.36,3.60)]显著相关。当前吸烟[OR 3.75(95%可信区间 1.54,9.15)]、从事体力劳动[OR 2.33(95%可信区间 1.17,4.64)]、病程较长[OR 1.01(95%可信区间 1.00,1.01)]和较低的 BMI[OR 0.90(95%可信区间 0.82,0.99)]与提前离开劳动力市场相关。

结论

RA 对中国患者的工作能力有很大影响。社会人口统计学、疾病和工作相关因素均与工作能力受损相关。

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