Department of Rheumatology and Immunology, People's Hospital, Peking University Health Science Center.
Department of Rheumatology and Immunology, Peking University Shougang Hospital.
Rheumatology (Oxford). 2015 Aug;54(8):1478-87. doi: 10.1093/rheumatology/kev014. Epub 2015 Mar 22.
To evaluate the impact of RA on work capacity and identify factors related to work capacity impairment in patients with RA.
A cross-sectional multicentre study was performed in 21 tertiary care hospitals across China. A consecutive sample of 846 patients with RA was recruited, of which 589 patients of working age at disease onset constituted the study population. Information on the socio-demographic, clinical, working and financial conditions of the patients was collected. Logistic regression analyses were used to identify factors associated with work capacity impairment.
The rate of work capacity impairment was 48.0% in RA patients with a mean disease duration of 60 months (interquartile range 14-134 months), including 11.7% leaving the labour force early, 33.6% working reduced hours and 2.7% changing job. Multivariable logistic regression analysis showed that reduced working hours was significantly related to current smoking [odds ratio (OR) 2.07 (95% CI 1.08, 3.97)], no insurance [OR 1.94 (95% CI 1.20, 3.12)], in manual labour [OR 2.66 (95% CI 1.68, 4.20)] and higher HAQ score [OR 2.22 (95% CI 1.36, 3.60)]. There was an association of current smoking [OR 3.75 (95% CI 1.54, 9.15)], in manual labour [OR 2.33 (95% CI 1.17, 4.64)], longer disease duration [OR 1.01 (95% CI 1.00, 1.01)] and lower BMI [OR 0.90 (95% CI 0.82, 0.99)] with leaving the labour force early.
There is a substantial impact of RA on the work capacity of patients in China. Social-demographic, disease- and work-related factors are all associated with work capacity impairment.
评估类风湿关节炎(RA)对工作能力的影响,并确定与 RA 患者工作能力受损相关的因素。
在中国 21 家三级护理医院进行了一项横断面多中心研究。共招募了 846 例 RA 连续样本患者,其中发病时处于工作年龄的 589 例患者构成了研究人群。收集了患者的社会人口统计学、临床、工作和财务状况信息。采用逻辑回归分析来确定与工作能力受损相关的因素。
在平均病程 60 个月(四分位间距 14-134 个月)的 RA 患者中,工作能力受损的发生率为 48.0%,包括 11.7%提前离开劳动力市场、33.6%工作时间减少和 2.7%换工作。多变量逻辑回归分析显示,工作时间减少与当前吸烟[比值比(OR)2.07(95%可信区间 1.08,3.97)]、无保险[OR 1.94(95%可信区间 1.20,3.12)]、从事体力劳动[OR 2.66(95%可信区间 1.68,4.20)]和较高的健康评估问卷(HAQ)评分[OR 2.22(95%可信区间 1.36,3.60)]显著相关。当前吸烟[OR 3.75(95%可信区间 1.54,9.15)]、从事体力劳动[OR 2.33(95%可信区间 1.17,4.64)]、病程较长[OR 1.01(95%可信区间 1.00,1.01)]和较低的 BMI[OR 0.90(95%可信区间 0.82,0.99)]与提前离开劳动力市场相关。
RA 对中国患者的工作能力有很大影响。社会人口统计学、疾病和工作相关因素均与工作能力受损相关。