Wang Jing, Chen Na, Fang Liang, Feng Zhe, Li Guochun, Mucelli Attilio, Zhang Xu, Zhou Xueping
The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
School of Health Economics and Management, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Evid Based Complement Alternat Med. 2018 Feb 8;2018:1567463. doi: 10.1155/2018/1567463. eCollection 2018.
Hook.f. (TWHF) is a traditional Chinese herb long used for rheumatoid arthritis (RA) treatment, in modern times, often in the form of various Hook.f. preparations (TWPs). This systematic review and meta-analysis focuses on analyzing the clinical efficacy and safety of TWPs in the treatment of RA. Databases were searched to collect the randomized controlled trials (RCTs) on TWPs treating RA published on or before April 10, 2017. Data from 11 studies were included in this meta-analysis. Compared with the control group, TWPs can increase effectiveness, while decreasing erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), C-reactive protein (CRP), and risk of adverse events. TWPs treatment was also more effective than treatment by conventional western medicine (CWM) and Chinese patent medicine or placebo (COP). TWPs significantly decreased the risk of adverse events compared with the CWM group, but not compared with the COP group. Current evidence shows that TWPs are more effective than other western or Chinese medicines we included in this meta-analysis for RA treatment with relatively lower toxicity.
雷公藤（TWHF）是一种长期用于治疗类风湿性关节炎（RA）的传统中药，在现代，通常以各种雷公藤制剂（TWPs）的形式使用。本系统评价和荟萃分析聚焦于分析TWPs治疗RA的临床疗效和安全性。通过检索数据库收集2017年4月10日及以前发表的关于TWPs治疗RA的随机对照试验（RCTs）。本荟萃分析纳入了11项研究的数据。与对照组相比，TWPs可提高疗效，同时降低红细胞沉降率（ESR）、类风湿因子（RF）、C反应蛋白（CRP）以及不良事件风险。TWPs治疗也比传统西药（CWM）和中成药或安慰剂（COP）治疗更有效。与CWM组相比，TWPs显著降低了不良事件风险，但与COP组相比则不然。目前的证据表明，在本荟萃分析中，TWPs治疗RA比我们纳入的其他西药或中药更有效，且毒性相对较低。
