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干扰素γ、白细胞介素-10和转化生长因子β基因的多态性可能与HIV-1感染有关。

Polymorphisms in the IFNγ, IL-10, and TGFβ genes may be associated with HIV-1 infection.

作者信息

Freitas Felipe Bonfim, Lima Sandra Souza, Feitosa Rosimar Neris Martins, Azevedo Vânia Nakauth, Ishak Marluísa de O Guimarães, Ishak Ricardo, Vallinoto Antonio Carlos R

机构信息

Laboratory of Virology, Biological Sciences Institute, Federal University of Pará, 66075-110 Belém, PA, Brazil.

出版信息

Dis Markers. 2015;2015:248571. doi: 10.1155/2015/248571. Epub 2015 Feb 24.

DOI:10.1155/2015/248571
PMID:25802474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4354727/
Abstract

OBJECTIVE

This study investigated possible associations between the TNFα-308G/A, IFN+874A/T, IL-6-174C/G, IL-10-1082A/G, and TGFβ-509C/T polymorphisms with HIV-1 infection, in addition to correlation of the polymorphisms with clinical markers of AIDS progression, such as levels of CD4+/CD8+ T lymphocytes and plasma viral load.

METHODS

A total of 216 individuals who were infected with HIV-1 and on antiretroviral therapy (ART) and 294 individuals from the uninfected control group were analyzed.

RESULTS

All individuals evaluated were negative for total anti-HBc, anti-HCV, anti-T. pallidum, and anti-HTLV-1/2. The polymorphisms were identified by PCR-RFLP. Individuals presenting the IFN+874A allele as well as the AA genotype were more frequent in the HIV-1 infected group compared to the control group (P < 0.05), in addition to having lower levels of CD4+ T lymphocytes. The CD8+ T lymphocytes count was significantly lower in individuals with the IL-10-1082 GG genotype. The TGFβ-509TT genotype was associated with higher plasma viral load.

CONCLUSIONS

The results suggest that the presence of the IFN+874A allele confers susceptibility to HIV-1 infection and a decrease in the number of CD4+ T lymphocytes. In addition, the genotype associated with high serum levels of TGFβ may be associated with an increase in plasma viral load.

摘要

目的

本研究调查了TNFα - 308G/A、IFN + 874A/T、IL - 6 - 174C/G、IL - 10 - 1082A/G和TGFβ - 509C/T基因多态性与HIV - 1感染之间可能存在的关联，此外还研究了这些多态性与艾滋病进展临床标志物的相关性，如CD4⁺/CD8⁺ T淋巴细胞水平和血浆病毒载量。

方法

对216例感染HIV - 1且正在接受抗逆转录病毒治疗（ART）的个体以及294例未感染的对照组个体进行了分析。

结果

所有评估个体的抗 - HBc、抗 - HCV、抗梅毒螺旋体和抗 - HTLV - 1/2检测均为阴性。通过PCR - RFLP鉴定基因多态性。与对照组相比，HIV - 1感染组中出现IFN + 874A等位基因以及AA基因型的个体更为常见（P < 0.05），且CD4⁺ T淋巴细胞水平较低。IL - 10 - 1082 GG基因型个体的CD8⁺ T淋巴细胞计数显著降低。TGFβ - 509TT基因型与较高的血浆病毒载量相关。

结论

结果表明，IFN + 874A等位基因的存在使个体易感染HIV - 1并导致CD4⁺ T淋巴细胞数量减少。此外，与高血清TGFβ水平相关的基因型可能与血浆病毒载量增加有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81ee/4354727/94a323a87a6e/DM2015-248571.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81ee/4354727/8ee3b11c666e/DM2015-248571.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81ee/4354727/774c2c63779d/DM2015-248571.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81ee/4354727/94a323a87a6e/DM2015-248571.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81ee/4354727/8ee3b11c666e/DM2015-248571.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81ee/4354727/774c2c63779d/DM2015-248571.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81ee/4354727/94a323a87a6e/DM2015-248571.003.jpg

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