Mueller R A, Towle A, Breese G R
Pharmacol Biochem Behav. 1985 Feb;22(2):221-5. doi: 10.1016/0091-3057(85)90381-8.
Adult awake rats which received neonatal pargyline and 5,7-dihydroxytryptamine to severely reduce CNS serotonin terminals and perikarya have a reduced rate of accumulation of brain stem 5-hydroxytryptophan after Ro-44602. The rate of accumulation in the cerebral cortex and spinal cord were near normal when adult, even though serotonin and 5-hydroxyindoleacetic acid were sharply reduced in these regions. The respiratory response to 5-methoxy N,N-dimethyl-tryptamine was much more pronounced in pargyline-5,7-dihydroxytryptamine treated rats than in controls. If supersensitivity in serotonin receptors only develops in areas with decreased transmitter turnover, the site of action of serotonin agonists to depress respiration would seem to reside in the brain stem region. The results also suggest that compensatory changes in turnover do not develop to a similar degree in all CNS areas with altered serotonin content.
接受新生期帕吉林和5,7-二羟基色胺以严重减少中枢神经系统血清素终末和胞体的成年清醒大鼠，在给予Ro-44602后脑干5-羟色氨酸的积累速率降低。成年时，尽管大脑皮层和脊髓中的血清素和5-羟吲哚乙酸急剧减少，但其积累速率接近正常。与对照组相比，帕吉林-5,7-二羟基色胺处理的大鼠对5-甲氧基-N,N-二甲基色胺的呼吸反应更为明显。如果血清素受体超敏仅在递质更新率降低的区域发生，那么血清素激动剂抑制呼吸的作用部位似乎位于脑干区域。结果还表明，在血清素含量改变的所有中枢神经系统区域，更新率的代偿性变化并未发展到相似程度。
