Mueller R A, Towle A C, Breese G R
Brain Res. 1984 Apr 30;298(2):370-3. doi: 10.1016/0006-8993(84)91440-9.
Rats treated neonatally with pargyline and 5,7-dihydroxytryptamine (5,7-DHT) have an elevated paCO2 and reduced minute ventilation when given 0.7% halothane in oxygen as adults. Serotonin content in the spinal cord of 5,7-DHT treated rats was undetectable and TRH content was reduced by 35%. The 5,7-DHT treated rats were supersensitive to the increase in minute ventilation and CO2 sensitivity produced by intraventricular TRH. It is possible that the supersensitivity to exogenous TRH after neonatal 5,7-DHT treatment may be secondary to decreased availability of TRH in the CNS.
新生期用优降宁和5,7-二羟基色胺（5,7-DHT）处理的大鼠成年后在吸入0.7%氟烷和氧气时，动脉血二氧化碳分压（PaCO2）升高，分钟通气量降低。5,7-DHT处理的大鼠脊髓中血清素含量无法检测到，促甲状腺激素释放激素（TRH）含量降低了35%。5,7-DHT处理的大鼠对脑室内注射TRH引起的分钟通气量增加和二氧化碳敏感性超敏感。新生期5,7-DHT处理后对外源性TRH的超敏感性可能继发于中枢神经系统中TRH可用性的降低。
