Bagdy G, Perényi A, Frecska E, Révai K, Papp Z, Fekete M I, Arató M
Psychopharmacology (Berl). 1985;85(1):62-4. doi: 10.1007/BF00427323.
Dopamine (DA), homovanillic acid (HVA), dihydroxyphenylacetic acid (DOPAC), noradrenaline (NA), and 5-hydroxyindolacetic acid (5HIAA) were measured in cerebrospinal fluid (CSF) of 15 chronic schizophrenic patients before and 2 weeks after withdrawal of long-term neuroleptic treatment. Total neuroleptic-like activity in serum (NLA) was determined at the same times. Levels of DA and its metabolites (DOPAC and HVA) and NA were significantly reduced after the discontinuation of neuroleptic treatment. No change was observed in 5HIAA values. NLA was substantially reduced, but still remained detectable. The decrease in DA, DOPAC, and HVA all showed positive correlations with each other, and correlated negatively with NLA measured after 2 weeks. Our data implies that the decrease in DA turnover is the result of the discontinuance of DA receptor blockade, while the change in NA level is independent of it.
在15例慢性精神分裂症患者长期停用抗精神病药物治疗前及停药2周后，测定其脑脊液（CSF）中的多巴胺（DA）、高香草酸（HVA）、二羟基苯乙酸（DOPAC）、去甲肾上腺素（NA）和5-羟吲哚乙酸（5HIAA）。同时测定血清中总抗精神病样活性（NLA）。停用抗精神病药物治疗后，DA及其代谢产物（DOPAC和HVA）以及NA的水平显著降低。5HIAA值未观察到变化。NLA大幅降低，但仍可检测到。DA、DOPAC和HVA的降低彼此均呈正相关，且与2周后测得的NLA呈负相关。我们的数据表明，DA周转率的降低是DA受体阻断剂停用的结果，而NA水平的变化与之无关。
