University of Antwerp, Universiteitsplein 1, 2610 Wilrijk (Antwerp), Belgium.
J Manag Care Spec Pharm. 2015 Apr;21(4):288-96. doi: 10.18553/jmcp.2015.21.4.288.
Generic medicines offer an opportunity for governments to contain pharmaceutical expenditures, since generics are generally 10%-80% lower in price than brand medicines. Belgium has a small generic market that takes up 15% of the total pharmaceutical market in packages sold.
To determine the knowledge of consumers about the different available packages of a common over-the-counter medicine (acetaminophen) with regard to price advantage, quality, and effectiveness in a country with a small generic market.
We conducted an online survey in the general Flemish population using a questionnaire with 25 statements. The questionnaire also contained 2 informative interventions. First, we showed the price per package and per tablet that the patient would pay in the pharmacy. Second, we provided the respondent with general information about generic medication (equivalence, effectiveness, price, and recognition). Before and after the interventions, we probed for preferences and knowledge about the different packages. Multivariate logistic models were used to examine the independent effects of consumer characteristics on responses to the survey statements.
We obtained a sample of 1,636 respondents. The general attitude towards generic medication was positive-only 5% would rather not use a generic. Nevertheless, only 17% of the respondents were able to recognize a generic medicine. Older consumers (aged 60 years and above) were more often confused about the different packages (OR = 2.59, 95% CI = 1.76-3.80, P ≤ 0.001). Consumers without a higher education degree tended to be more doubtful about the difference in effectiveness and quality between the different brands (OR = 0.59, 95% CI = 0.44-0.79, P ≤ 0.001). Consumer recognition of the name of the active substance of acetaminophen was poor. When different brands were displayed, possible price advantage seemed to be an important motive to switch to a cheaper brand. Consumers generally found medicines to be too expensive; however, consumers with medical or paramedical training had a different opinion.
Two main recommendations can be made to increase the knowledge and enhance the trust in cheaper equivalent medicines. First, highlighting the name of the active substance on the label of medicine packages can reduce confusion and avoid health risks, especially among older consumers. Second, new investments or reallocation of budgets should be considered in order to provide consumers with authoritative information on the bioequivalence and price differences between the different available brands. This would be a cost-effective and potentially cost-saving investment for health care payers.
仿制药为政府控制药品支出提供了机会,因为仿制药的价格通常比品牌药低 10%-80%。比利时的仿制药市场规模较小,在销售的药品总量中占 15%。
在一个仿制药市场较小的国家,确定消费者对一种常见非处方药(对乙酰氨基酚)的不同包装在价格优势、质量和疗效方面的认知。
我们在普通佛兰德人群中进行了一项在线调查,使用了一份包含 25 个陈述的问卷。问卷还包含了 2 个信息干预措施。首先,我们展示了患者在药房购买每盒和每片药品的价格。其次,我们向受访者提供了关于仿制药的一般信息(等效性、疗效、价格和认可度)。在干预前后,我们调查了受访者对不同包装的偏好和认知。使用多变量逻辑模型来检验消费者特征对调查陈述的独立影响。
我们获得了 1636 名受访者的样本。他们对仿制药的总体态度是积极的,只有 5%的人表示不愿意使用仿制药。然而,只有 17%的受访者能够识别出一种仿制药。年龄较大的消费者(60 岁及以上)对不同包装的困惑程度更高(OR=2.59,95%CI=1.76-3.80,P≤0.001)。没有高等教育学历的消费者往往对不同品牌之间的疗效和质量差异更加怀疑(OR=0.59,95%CI=0.44-0.79,P≤0.001)。消费者对乙酰氨基酚活性物质名称的认知度较差。当显示不同品牌时,可能的价格优势似乎是转向更便宜品牌的重要动机。消费者普遍认为药品太贵;然而,有医疗或辅助医疗培训背景的消费者则有不同的看法。
为了提高对更便宜等效药品的认知和信任,可以提出两项主要建议。首先,在药品包装标签上突出活性物质的名称,可以减少混淆,避免健康风险,特别是在老年消费者中。其次,应考虑新的投资或重新分配预算,以便向消费者提供关于不同可用品牌之间生物等效性和价格差异的权威信息。这将是一种具有成本效益的投资,也可能为医疗保健支付者节省成本。