Ghalib H W, Cherrington J M, Osburn B I
Vet Microbiol. 1985 Jan;10(2):179-88. doi: 10.1016/0378-1135(85)90019-7.
Sheep were experimentally infected with cloned strains of tissue culture adapted bluetongue virus (BTV) serotypes 10, 11, 13 and 17. All the infected animals developed viremia by Day 2 or 3 post-inoculation (P.I.) and reached maximum viremia on Day 7 P.I. The viremia lasted for 2 to 3 weeks. Animals infected with the different serotypes showed mild clinical bluetongue (BT) responses, characterized by pyrexia and leukopenia, which coincided with the peak of viremia. Antibodies appeared by Day 10 P.I. and reached maximum by Day 28 P.I. There was a temporal relationship between the increase in neutralizing antibody titer, the drop in titer and clearance of virus from the peripheral circulation. Recovery from primary infection protected the animals against secondary challenge with homologous virus.
用组织培养适应型蓝舌病病毒（BTV）血清型10、11、13和17的克隆毒株对绵羊进行实验性感染。所有感染动物在接种后第2天或第3天出现病毒血症，并在接种后第7天达到病毒血症高峰。病毒血症持续2至3周。感染不同血清型的动物表现出轻度临床蓝舌病（BT）反应，特征为发热和白细胞减少，这与病毒血症高峰一致。抗体在接种后第10天出现，并在接种后第28天达到最高水平。中和抗体滴度的升高、滴度的下降与病毒从外周循环中清除之间存在时间关系。初次感染后的恢复使动物对同源病毒的二次攻击具有保护作用。
