Coutinho Joana Fernandes, Fernandesl Sara Veiga, Soares José Miguel, Maia Liliana, Gonçalves Óscar Filipe, Sampaio Adriana
Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal.
Life and Health Sciences Research Institute and ICVS-3Bs PT Government Associate Laboratory, Universityof Minho, Braga, Portugal.
Brain Imaging Behav. 2016 Mar;10(1):147-57. doi: 10.1007/s11682-015-9375-7.
The resting state brain networks, particularly the Default Mode Network (DMN), have been found to be altered in several psychopathological conditions such as depression and anxiety. In this study we hypothesized that cortical areas of the DMN, particularly the anterior regions--medial prefrontal cortex and anterior cingulate cortex--would show an increased functional connectivity associated with both anxiety and depression. Twenty-four healthy participants were assessed using Hamilton Depression and Anxiety Rating Scales and completed a resting-state functional magnetic resonance imaging scan. Multiple regression was performed in order to identify which areas of the DMN were associated with anxiety and depression scores. We found that the functional connectivity of the anterior portions of DMN, involved in self-referential and emotional processes, was positively correlated with anxiety and depression scores, whereas posterior areas of the DMN, involved in episodic memory and perceptual processing were negatively correlated with anxiety and depression scores. The dissociation between anterior and posterior cortical midline regions, raises the possibility of a functional specialization within the DMN in terms of self-referential tasks and contributes to the understanding of the cognitive and affective alterations in depressive and anxiety states.
静息态脑网络，尤其是默认模式网络（DMN），已被发现在诸如抑郁和焦虑等多种精神病理状况下会发生改变。在本研究中，我们假设DMN的皮质区域，特别是前部区域——内侧前额叶皮质和前扣带回皮质——会表现出与焦虑和抑郁相关的功能连接增加。使用汉密尔顿抑郁和焦虑评定量表对24名健康参与者进行评估，并完成静息态功能磁共振成像扫描。进行多元回归以确定DMN的哪些区域与焦虑和抑郁评分相关。我们发现，参与自我参照和情绪过程的DMN前部的功能连接与焦虑和抑郁评分呈正相关，而参与情景记忆和知觉加工的DMN后部区域与焦虑和抑郁评分呈负相关。皮质中线前后区域之间的分离，增加了DMN在自我参照任务方面功能特化的可能性，并有助于理解抑郁和焦虑状态下的认知和情感改变。
