Dalgleish Angus G
Immunotherapy. 2015;7(3):309-16. doi: 10.2217/imt.14.111.
Immunotherapy has usually been considered as an alternative to more traditional modalities. Moreover, it has previously been felt that chemotherapy is inherently immunosuppressive and not suitable for combining with immunotherapy. In this review, the concept of combining different modalities that result in cell death, such as radiotherapy and chemotherapy, with immunotherapy is explored. Tumors actively cause immune suppression which can be reversed by their removal but when this is not possible, enhancing the immune response with nonspecific immune stimulation can enhance the response to other modalities, such as radiotherapy and chemotherapy. Additionally, several chemotherapy agents at low doses selectively inhibit regulatory and suppressor cells.
免疫疗法通常被视为更传统治疗方式的替代方法。此外，过去人们认为化疗本质上具有免疫抑制作用，不适合与免疫疗法联合使用。在本综述中，探讨了将放疗和化疗等导致细胞死亡的不同治疗方式与免疫疗法相结合的概念。肿瘤会主动引起免疫抑制，切除肿瘤可逆转这种抑制，但在无法切除肿瘤时，通过非特异性免疫刺激增强免疫反应可提高对放疗和化疗等其他治疗方式的反应。此外，低剂量的几种化疗药物可选择性抑制调节性细胞和抑制性细胞。
