Abdelkhalik Ashraf M, Paul Nawal K, Jha Amitabh
Department of Chemistry, Acadia University, Wolfville, NS, Canada.
Department of Chemistry, Acadia University, Wolfville, NS, Canada.
Steroids. 2015 Jun;98:107-13. doi: 10.1016/j.steroids.2015.03.010. Epub 2015 Mar 21.
A concise method for the synthesis of 14-azasteroid analogs with angular methyl group at C-13 of the steroidal nucleus has been reported in this paper. We have developed an interesting cascade reaction of arylacetylenes and N-(naphthalen-2-yl)pent-4-ynamides under gold (III)-catalysis to produce novel tetracyclic 12a-methyl-11-aryl-1,2-dihydrobenzo[f]pyrrolo[1,2-a]quinolin-3(12aH)-ones which may be viewed as 14-azaestrogen analogs.
本文报道了一种简洁的方法来合成甾体核C-13位带有角甲基的14-氮杂甾体类似物。我们开发了一种在金（III）催化下芳基乙炔与N-（萘-2-基）戊-4-炔酰胺的有趣级联反应，以生成新型四环12a-甲基-11-芳基-1,2-二氢苯并[f]吡咯并[1,2-a]喹啉-3（12aH）-酮，其可被视为14-氮杂雌激素类似物。
