• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

大鼠三叉神经节单细胞中降钙素基因相关肽与P物质样肽的共存：免疫组织化学分析

Coexistence of calcitonin gene-related peptide and substance P-like peptide in single cells of the trigeminal ganglion of the rat: immunohistochemical analysis.

作者信息

Lee Y, Kawai Y, Shiosaka S, Takami K, Kiyama H, Hillyard C J, Girgis S, MacIntyre I, Emson P C, Tohyama M

出版信息

Brain Res. 1985 Mar 18;330(1):194-6. doi: 10.1016/0006-8993(85)90027-7.

DOI:10.1016/0006-8993(85)90027-7
PMID:2580592
Abstract

The localization of calcitonin gene-related peptide (CGRP) and substance P (SP) in the rat trigeminal ganglion was examined by means of the indirect immunofluorescent method. About 40% of neurons in the ganglion contained CGRP-like immunoreactivity (CGRPI), while about 20% of neurons showed SP-like immunoreactivity (SPI). In serial sections, nearly all the SPI neurons contained CGRPI.

摘要

采用间接免疫荧光法检测大鼠三叉神经节中降钙素基因相关肽（CGRP）和P物质（SP）的定位。神经节中约40%的神经元含有降钙素基因相关肽样免疫反应性物质（CGRPI），而约20%的神经元呈现P物质样免疫反应性物质（SPI）。在连续切片中，几乎所有的SPI神经元都含有CGRPI。

相似文献

1
Coexistence of calcitonin gene-related peptide and substance P-like peptide in single cells of the trigeminal ganglion of the rat: immunohistochemical analysis.大鼠三叉神经节单细胞中降钙素基因相关肽与P物质样肽的共存：免疫组织化学分析
Brain Res. 1985 Mar 18;330(1):194-6. doi: 10.1016/0006-8993(85)90027-7.
2
Two distinct calcitonin gene-related peptide-containing peripheral nervous systems: distribution and quantitative differences between the iris and cerebral artery with special reference to substance P.两种不同的含降钙素基因相关肽的外周神经系统：虹膜与脑动脉之间的分布及定量差异，并特别提及P物质
Brain Res. 1986 May 14;373(1-2):205-12. doi: 10.1016/0006-8993(86)90332-x.
3
Origins and distribution of calcitonin gene-related peptide-containing nerves in the wall of the cerebral arteries of the guinea pig with special reference to the coexistence with substance P.
Brain Res. 1986 Mar 26;369(1-2):185-92. doi: 10.1016/0006-8993(86)90527-5.
4
Neuropeptide immunoreactivity of pericellular baskets in the guinea pig trigeminal ganglion.
Neurosci Lett. 1986 Feb 28;64(2):169-72. doi: 10.1016/0304-3940(86)90094-7.
5
Distribution and origin of calcitonin gene-related peptide (CGRP) immunoreactivity in the sensory innervation of the mammalian eye.降钙素基因相关肽（CGRP）免疫反应性在哺乳动物眼部感觉神经支配中的分布与起源
J Comp Neurol. 1985 Mar 22;233(4):506-16. doi: 10.1002/cne.902330410.
6
Existence and coexistence of calcitonin gene-related peptide (CGRP) and substance P in cerebrovascular nerves and trigeminal ganglion cells.降钙素基因相关肽（CGRP）与P物质在脑血管神经及三叉神经节细胞中的存在与共存
Acta Physiol Scand Suppl. 1986;552:29-32.
7
Co-localization of calcitonin gene-related peptide-like immunoreactivity with substance P in cutaneous, vascular and visceral sensory neurons of guinea pigs.降钙素基因相关肽样免疫反应性与P物质在豚鼠皮肤、血管和内脏感觉神经元中的共定位。
Neurosci Lett. 1985 Jun 12;57(2):125-30. doi: 10.1016/0304-3940(85)90050-3.
8
Cholecystokinin-like immunoreactivity occurs in ocular sensory neurons and partially co-localizes with substance P.胆囊收缩素样免疫反应出现在眼感觉神经元中，并部分与P物质共定位。
Brain Res. 1986 Sep 3;381(2):266-74. doi: 10.1016/0006-8993(86)90076-4.
9
Release of the predicted calcitonin gene-related peptide from cultured rat trigeminal ganglion cells.从培养的大鼠三叉神经节细胞中释放预测的降钙素基因相关肽。
Nature. 1984;308(5960):653-5. doi: 10.1038/308653a0.
10
Calcitonin gene-related peptide in the human trigeminal sensory system at developmental and adult life stages: immunohistochemistry, neuronal morphometry and coexistence with substance P.人三叉神经感觉系统发育和成年阶段的降钙素基因相关肽：免疫组织化学、神经元形态测定及与P物质共存
J Chem Neuroanat. 1992 Mar-Apr;5(2):143-57. doi: 10.1016/0891-0618(92)90040-w.

引用本文的文献

1
Elucidation of the treatment mechanism of pulsed radiofrequency based on its antiinflammatory effects.基于其抗炎作用阐明脉冲射频的治疗机制。
Sci Rep. 2025 Sep 29;15(1):33611. doi: 10.1038/s41598-025-19045-z.
2
Chronification of migraine sensitizes to CGRP in male and female mice.偏头痛的慢性化使雄性和雌性小鼠对降钙素基因相关肽（CGRP）敏感。
Cephalalgia. 2025 Feb;45(2):3331024251317446. doi: 10.1177/03331024251317446.
3
Sensory neuronal control of skin barrier immunity.感觉神经元对皮肤屏障免疫的控制。
Trends Immunol. 2024 May;45(5):371-380. doi: 10.1016/j.it.2024.03.008. Epub 2024 Apr 22.
4
CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond.降钙素基因相关肽的生理学、药理学和治疗靶点：偏头痛及其他。
Physiol Rev. 2023 Apr 1;103(2):1565-1644. doi: 10.1152/physrev.00059.2021. Epub 2022 Dec 1.
5
A narrative review of the calcitonin peptide family and associated receptors as migraine targets: Calcitonin gene-related peptide and beyond.降钙素肽家族及其相关受体作为偏头痛靶点的叙述性综述：降钙素基因相关肽及其他。
Headache. 2022 Oct;62(9):1093-1104. doi: 10.1111/head.14388. Epub 2022 Oct 13.
6
Ocular Autonomic Nervous System: An Update from Anatomy to Physiological Functions.眼自主神经系统：从解剖学到生理功能的最新进展
Vision (Basel). 2022 Jan 14;6(1):6. doi: 10.3390/vision6010006.
7
Crosstalk Between Epithelial Cells, Neurons and Immune Mediators in HSV-1 Skin Infection.HSV-1 皮肤感染中上皮细胞、神经元和免疫介质之间的串扰。
Front Immunol. 2021 May 3;12:662234. doi: 10.3389/fimmu.2021.662234. eCollection 2021.
8
Hemokinin-1 Gene Expression Is Upregulated in Trigeminal Ganglia in an Inflammatory Orofacial Pain Model: Potential Role in Peripheral Sensitization.在炎症性口面疼痛模型中，三叉神经节中血激肽-1 基因表达上调：在外周致敏中的潜在作用。
Int J Mol Sci. 2020 Apr 22;21(8):2938. doi: 10.3390/ijms21082938.
9
Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators.三叉神经节中的串扰信号：神经肽和其他介质的作用。
J Neural Transm (Vienna). 2020 Apr;127(4):431-444. doi: 10.1007/s00702-020-02161-7. Epub 2020 Feb 22.
10
TRP Channels in the Focus of Trigeminal Nociceptor Sensitization Contributing to Primary Headaches.TRP 通道在三叉神经伤害感受器致敏中的作用与原发性头痛有关。
Int J Mol Sci. 2020 Jan 4;21(1):342. doi: 10.3390/ijms21010342.