Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine Houston, TX, USA.
Department of Neuroscience, Baylor College of Medicine Houston, TX, USA.
Front Hum Neurosci. 2015 Mar 9;9:116. doi: 10.3389/fnhum.2015.00116. eCollection 2015.
Abnormal interhemispheric functional connectivity correlates with several neurologic and psychiatric conditions, including depression, obsessive-compulsive disorder, schizophrenia, and stroke. Abnormal interhemispheric functional connectivity also correlates with abuse of cannabis and cocaine. In the current report, we evaluated whether tobacco abuse (i.e., cigarette smoking) is associated with altered interhemispheric connectivity. To that end, we examined resting state functional connectivity (RSFC) using magnetic resonance imaging (MRI) in short term tobacco deprived and smoking as usual tobacco smokers, and in non-smoker controls. Additionally, we compared diffusion tensor imaging (DTI) in the same subjects to study differences in white matter. The data reveal a significant increase in interhemispheric functional connectivity in sated tobacco smokers when compared to controls. This difference was larger in frontal regions, and was positively correlated with the average number of cigarettes smoked per day. In addition, we found a negative correlation between the number of DTI streamlines in the genual corpus callosum and the number of cigarettes smoked per day. Taken together, our results implicate changes in interhemispheric functional and anatomical connectivity in current cigarette smokers.
异常的大脑两半球间功能连接与多种神经和精神疾病有关，包括抑郁症、强迫症、精神分裂症和中风。异常的大脑两半球间功能连接也与大麻和可卡因的滥用有关。在目前的报告中，我们评估了吸烟是否与大脑两半球间连接的改变有关。为此，我们使用磁共振成像（MRI）在短期戒烟和习惯性吸烟的吸烟者以及非吸烟者对照中检查了静息状态功能连接（RSFC）。此外，我们在相同的受试者中比较了弥散张量成像（DTI），以研究白质的差异。数据显示，与对照组相比，满足感的吸烟者大脑两半球间的功能连接明显增加。这种差异在前额区域更大，并与每天吸烟的平均数量呈正相关。此外，我们发现胼胝体膝部的 DTI 流线数量与每天吸烟的数量之间存在负相关。总之，我们的结果表明，目前吸烟的吸烟者大脑两半球间功能和解剖连接发生了变化。
