Morera Carles, Sabates Santiago, Jaen Angeles
Cirurgia Ortopèdica i Traumatologia de Catalunya, COTCAT, Hospital Universitari Mutua de Terrassa, 08221 Terrassa, Barcelona, Spain.
Pain Manag. 2015;5(2):81-7. doi: 10.2217/pmt.15.5.
Response to N-palmitoylethanolamide (PEA) appear to be influenced by hormonal changes.
To evaluate sex differences in the effectiveness of PEA.
Patients with neuropathic pain resulting from lumbosciatalgia were assigned to conventional treatment plus PEA or conventional treatment. The pain variables were measured using a visual analog scale and quality of life was assessed.
One hundred and twelve patients were included. Significant differences were seen in men for all the variables. In women the differences were only significant for pain. A multivariate linear regression analysis showed a positive interaction between men and PEA treatment for the SF-12 mental component.
Men treated with PEA are more likely to improve their quality of life regarding mental health, compared with women.
对N-棕榈酰乙醇胺（PEA）的反应似乎受激素变化影响。
评估PEA有效性的性别差异。
将因腰骶神经痛导致神经性疼痛的患者分为接受常规治疗加PEA组或常规治疗组。使用视觉模拟量表测量疼痛变量并评估生活质量。
纳入112例患者。所有变量在男性中均存在显著差异。在女性中，差异仅在疼痛方面显著。多因素线性回归分析显示，男性与PEA治疗对SF-12精神成分存在正性交互作用。
与女性相比，接受PEA治疗的男性在心理健康方面更有可能改善生活质量。
