The molecular pharmacology of volatile anesthetics.
作者信息
Borghese Cecilia M
机构信息
Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas.
出版信息
Int Anesthesiol Clin. 2015 Spring;53(2):28-39. doi: 10.1097/AIA.0000000000000060.
Abstract
摘要
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X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.X 射线结构的 GluCl 在apo 状态揭示了 Cys 环受体的门控机制。
Nature. 2014 Aug 21;512(7514):333-7. doi: 10.1038/nature13669.
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X-ray structure of the mouse serotonin 5-HT3 receptor.鼠 5-羟色胺 5-HT3 受体的 X 射线结构。
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Crystal structure of a human GABAA receptor.人类 GABA 受体的晶体结构。
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GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites.GABA(A) 受体跨膜氨基酸对酒精作用至关重要：二硫键交联和烷基亚磺酰甲基硫醚标记揭示了结合位点的相对位置。
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Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels.配体门控离子通道新型麻醉剂虚拟筛选的功能验证。
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Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites.配体门控离子通道的抑制作用和增强作用可以通过一个单一的突变来改变，该突变将配体在亚基内和亚基间的位置之间移动。
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Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel.配体门控离子通道中增强作用的醇和麻醉剂的结构基础。
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Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC).普遍麻醉剂与原核五聚体菊欧文氏菌配体门控离子通道（ELIC）的多位点结合。
J Biol Chem. 2013 Mar 22;288(12):8355-8364. doi: 10.1074/jbc.M112.424507. Epub 2013 Jan 30.
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Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines.五聚体配体门控离子通道 ELIC 被 GABA 激活，并受苯二氮䓬类药物调节。
Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3028-34. doi: 10.1073/pnas.1208208109. Epub 2012 Oct 3.
10
General anesthetics predicted to block the GLIC pore with micromolar affinity.一般麻醉剂预计以微摩尔亲和力阻断 GLIC 孔。
PLoS Comput Biol. 2012 May;8(5):e1002532. doi: 10.1371/journal.pcbi.1002532. Epub 2012 May 31.
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