Eilat D, Fischel R, Zlotnick A
Eur J Immunol. 1985 Apr;15(4):375-81. doi: 10.1002/eji.1830150413.
The monoclonal A52 (IgG2b, kappa) anti-DNA autoantibody represents a major cross-reactive idiotype in the murine and human autoimmune response to DNA. Examination of sera and purified IgG derived from (NZB X NZW)F1 mice showed that these mice develop an age-dependent binding reactivity with the pure anti-DNA IgG. Three monoclonal antibodies possessing this reactivity were prepared from unprimed female (NZB X NZW)F1 mice. One of these monoclonal antibodies appeared to be directed against allotypic determinants present in the NZB IgG2b; the other two antibodies exhibited a marked preference for idiotypic determinants of the A52 IgG. The IgG anti-allotype and anti-idiotype activities in (NZB X NZW)F1 mice may, therefore, represent the products of a deregulated immune system and/or constitute the normal elements of a functional immune regulation system.
单克隆A52（IgG2b，κ）抗DNA自身抗体是小鼠和人类对DNA自身免疫反应中的一种主要交叉反应独特型。对（NZB×NZW）F1小鼠的血清和纯化IgG进行检测发现，这些小鼠对纯抗DNA IgG产生了年龄依赖性结合反应。从未经免疫的雌性（NZB×NZW）F1小鼠中制备了三种具有这种反应性的单克隆抗体。其中一种单克隆抗体似乎针对NZB IgG2b中存在的同种异型决定簇；另外两种抗体对A52 IgG的独特型决定簇表现出明显的偏好。因此，（NZB×NZW）F1小鼠中的IgG抗同种异型和抗独特型活性可能代表了失调免疫系统的产物和/或构成了功能性免疫调节系统的正常成分。
