Deer Rachel R, Volpi Elena
aSealy Center on Aging bDepartment of Internal Medicine cDepartment of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas, USA.
Curr Opin Clin Nutr Metab Care. 2015 May;18(3):248-53. doi: 10.1097/MCO.0000000000000162.
We provide an update on the recent advances in nutrition research regarding the role of protein intake in the development and treatment of sarcopenia of aging.
Specific muscle mass, strength and function cut-points for the diagnosis of sarcopenia have been identified. There is mounting evidence, as highlighted by multiple consensus statements, that the Recommended Dietary Allowance (0.8 g/kg body weight) may be inadequate to promote optimal health in older adults. Recent research indicates that in addition to total daily protein intake the timing of protein intake is also important to best stimulate muscle protein synthesis, and maintain muscle mass and function in older adults.
Recent evidence suggests that the Recommended Dietary Allowance for protein is inadequate, and that the timing and distribution of protein consumption throughout daily meals may be as important as the total quantity. Research has continued to advance our understanding of protein's effects on muscle metabolism; however, there remains a need for large, long-term, randomized clinical trials examining whether the positive effects of dietary protein on muscle metabolism seen in acute studies will translate over the long term into gains of muscle mass, function, and the overall health of older adults.
我们提供近期营养研究进展的最新情况，内容涉及蛋白质摄入在衰老性肌肉减少症发生发展及治疗中的作用。
已确定用于诊断肌肉减少症的特定肌肉质量、力量和功能切点。正如多项共识声明所强调的，越来越多的证据表明，推荐膳食摄入量（0.8克/千克体重）可能不足以促进老年人的最佳健康状态。近期研究表明，除了每日蛋白质总摄入量外，蛋白质摄入时间对于最佳刺激老年人肌肉蛋白质合成、维持肌肉质量和功能也很重要。
近期证据表明，蛋白质的推荐膳食摄入量并不充足，且每日餐食中蛋白质消耗的时间和分布可能与总量同样重要。研究不断推进我们对蛋白质对肌肉代谢影响的理解；然而，仍需要大型、长期、随机临床试验来检验急性研究中所见膳食蛋白质对肌肉代谢的积极影响是否能长期转化为老年人肌肉质量、功能及整体健康状况的改善。
