[Effect of natural neurotensin and its analog on gastric secretion and levels of various peptides in dog blood].

I.v. administration of neurotensin and its analogue DTch1I--neurotensin considerably decreased stomach secretion induced with pentagastrin but did not suppress stomach secretion induced with histamine, neither a microapplication of 10 micrograms in 3 microliter of neurotensin affected the secretion whereas the dose 50 micrograms in 3 microliter decreased both volume and acidity of the juice. I.v. administration of neurozensin increased the gastrin, neurotensin and the substance P contents in the dog blood. Microapplication of neurotensin to the globus pallidus with simultaneous i.v. administration of histamine increased the level of the serum gastrin.