Krzeminski Patryk
Postepy Biochem. 2014;60(4):490-505.
Despite a great scientific effort, the causes, development as well as progression of many tumors still remains unknown. Since that, it is important to investigate possible mechanisms which may lead to better understanding of cancer biology. Nucleotide and adenosine receptors may be consider as a promising direction of anti-tumor scientific research. Nucleotide receptors P2 and adenosine receptors P1 forms a great family of proteins whose activity has been proved to be involved in many cellular processes vital for tumorogenesis. This review gives basic insights into the mechanisms of proproliferative as well as antiproliferative action of nucleotide receptors in tumor cells.
尽管付出了巨大的科学努力，但许多肿瘤的病因、发展及进展仍然不明。因此，研究可能的机制以更好地理解癌症生物学很重要。核苷酸和腺苷受体可能被视为抗肿瘤科研的一个有前景的方向。核苷酸受体P2和腺苷受体P1构成了一个庞大的蛋白质家族，其活性已被证明参与了许多对肿瘤发生至关重要的细胞过程。本综述对核苷酸受体在肿瘤细胞中的促增殖和抗增殖作用机制进行了基本的阐述。
