Department of Life Science and Biotechnology, University of Ferrara, Ferrara, Italy.
Laboratory of Immunogenetics and CeRMS, Department of Medical Sciences, University of Torino and Transplant Immunology, Città della Salute e della Scienza, Torino, Italy.
Trends Pharmacol Sci. 2017 Mar;38(3):277-290. doi: 10.1016/j.tips.2016.11.010. Epub 2016 Dec 16.
Nucleotides and nucleosides have emerged as important modulators of tumor biology. Recently acquired evidence shows that, when these molecules are released by cancer cells or surrounding tissues, they act as potent prometastatic factors, favoring tumor cell migration and tissue colonization. Therefore, nucleotides and nucleosides should be considered as a new class of prometastatic factors. In this review, we focus on the prometastatic roles of nucleotides and discuss future applications of purinergic signaling modulation in view of antimetastatic therapies.
核苷酸和核苷已成为肿瘤生物学的重要调节剂。最近获得的证据表明，当这些分子由癌细胞或周围组织释放时，它们充当强大的促转移因子，有利于肿瘤细胞迁移和组织定植。因此，核苷酸和核苷应被视为一类新的促转移因子。在这篇综述中，我们重点讨论了核苷酸的促转移作用，并讨论了嘌呤能信号转导调节在抗转移治疗中的未来应用。
