Milenkovic Vladimir M, Rupprecht Rainer, Wetzel Christian H
Department of Psychiatry and Psychotherapy, Molecular Neurosciences, University of Regensburg, Franz- Josef-Strauss-Allee 11, D-93053 Regensburg, Germany.
Mini Rev Med Chem. 2015;15(5):366-72. doi: 10.2174/1389557515666150324122642.
The translocator protein 18 kDa (TSPO) is localized in the outer mitochondrial membrane of many cell types and its expression is found to be up-regulated under various pathological conditions such as cancer, inflammation, mechanical lesions, and neurological diseases, e.g. amyotrophic lateral sclerosis (ALS). Its primary function is to mediate the transport of cholesterol into the inner compartments of mitochondria. Moreover, TSPO is interacting and building up functional complexes with other mitochondrial proteins such as the voltage-dependent anion channel (VDAC), the adenine nucleotide transporter (ANT), hexokinase I and II and Glycogen synthase kinase 3 beta (GSK3β). This mini review will focus on the role of TSPO as a central regulator of mitochondrial function with regard to pathologic states and as a target for new therapeutic strategies for the treatment of psychiatric disorders.
18 kDa转运蛋白（TSPO）定位于多种细胞类型的线粒体外膜，发现在各种病理条件下，如癌症、炎症、机械损伤和神经疾病（如肌萎缩侧索硬化症，ALS），其表达会上调。其主要功能是介导胆固醇转运至线粒体内腔。此外，TSPO与其他线粒体蛋白相互作用并形成功能复合物，如电压依赖性阴离子通道（VDAC）、腺嘌呤核苷酸转运体（ANT）、己糖激酶I和II以及糖原合酶激酶3β（GSK3β）。本综述将聚焦于TSPO在病理状态下作为线粒体功能的核心调节因子的作用，以及作为治疗精神疾病新治疗策略靶点的作用。
