Sherman L A, Riblet R
J Immunol. 1985 Jun;134(6):3569-73.
Previous studies in which the H-2Kb-specific cytolytic T lymphocytes (CTL) receptor repertoires were compared for murine strains that express different Igh alleles (C.B-20 and BALB/c) indicated that Igh-linked genes affected the composition of the expressed CTL receptor repertoire. To confirm this genetic localization, and also to individually assess the contributions of Igh-V- and Igh-C-linked genes to CTL repertoire expression, the H-2Kb-specific responses of two Igh recombinant strains, BAB/14 (Igh-Va-Cb) and C.B/R3 (Igh-Vb-Ca), were analyzed. The results indicate that strains which share Igh-V (but not Igh-C) genes demonstrate significant repertoire similarities, whereas strains which share Igh-C (but not Igh-V) are no more similar than strains dissimilar throughout the Igh complex. These results are discussed in the context of the existence of a naturally occurring idiotypic network involving immunoglobulin and CTL receptors.
先前的研究比较了表达不同Igh等位基因的小鼠品系（C.B-20和BALB/c）的H-2Kb特异性细胞溶解T淋巴细胞（CTL）受体库，结果表明Igh连锁基因影响了所表达的CTL受体库的组成。为了证实这种基因定位，并单独评估Igh-V和Igh-C连锁基因对CTL受体库表达的贡献，分析了两个Igh重组品系BAB/14（Igh-Va-Cb）和C.B/R3（Igh-Vb-Ca）的H-2Kb特异性反应。结果表明，共享Igh-V（而非Igh-C）基因的品系表现出显著的受体库相似性，而共享Igh-C（而非Igh-V）的品系并不比在整个Igh复合体中都不同的品系更相似。本文在涉及免疫球蛋白和CTL受体的天然独特型网络存在的背景下讨论了这些结果。
